Mitragyna speciosa Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

botanical species; Rubiaceae plant containing indole alkaloids compound Reference needs_revision Best effort · source review pending

Also known as: kratom, Mitragyna speciosa Korth., Mitragyna speciosa (Korth.) Havil., Nauclea speciosa, Stephegyne speciosa, biak, katawn

Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes
Not standardized / source review pending
Components
mitragynine + 7-hydroxymitragynine + speciogynine + speciociliatine + paynantheine + corynantheidine

Blend Components

This entry is a multi-compound blend. Each component can be opened individually in the reconstitution calculator.

Component
mitragynine
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Component
7-hydroxymitragynine
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Component
speciogynine
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Component
speciociliatine
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Component
paynantheine
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Component
corynantheidine
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Component amounts shown are arithmetic starters based on equal distribution. Edit values in the calculator before saving.

Best-Effort Research Profile

Mitragyna speciosa is a wet-tropical tree in the family Rubiaceae. Botanical sources recognize it as an accepted species with a native range extending from southern Indochina through Malesia to New Guinea. Kratom leaf material is a complex botanical matrix rather than a single purified chemical and contains numerous indole and related alkaloids. The best-studied constituents are mitragynine and 7-hydroxymitragynine, which have partial opioid-receptor activity and are associated in the literature with stimulant, analgesic, euphoric, sedative, and opioid-like effects. Chemical composition varies with plant material, geography, season, plant age, and processing.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Administration Routes (Research)
oral

Reported Research Effects

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

This record represents a botanical species, not a single purified compound; therefore molecular identifiers, solubility, standardized storage conditions, species-level half-life, onset, and scientific common reference sizes are not assigned. Pharmacokinetic values reported for mitragynine, including an estimated half-life of approximately 3–9 hours, apply to that isolated constituent or its exposure after kratom administration and should not be treated as properties of Mitragyna speciosa itself. Published evidence includes laboratory, animal, pharmacokinetic, observational, and review literature; composition and effects are preparation-dependent. No FDA-approved drug containing kratom or kratom-derived substances was identified in the cited FDA assessment.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

Accepted botanical name: Mitragyna speciosa Korth.; alternative combination: Mitragyna speciosa (Korth.) Havil.; family: Rubiaceae; order: Gentianales. Kew lists Nauclea speciosa and Stephegyne speciosa as homotypic synonyms. No unique small-molecule CAS or molecular formula is applicable to the species-level botanical material.

Source-Backed Observations

Mitragynine is the principal alkaloid reported in kratom leaves. 7-Hydroxymitragynine is a naturally occurring minor constituent of botanical kratom and is generally present at substantially lower concentrations than mitragynine. Alkaloid profiles are variable, and concentrated or chemically enhanced products should not be assumed to represent the composition of untreated botanical leaf material.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

An update on the clinical pharmacology of kratom: uses, abuse potential and future considerations
https://pmc.ncbi.nlm.nih.gov/articles/PMC10846393/ (accessed 2026-09-20)
7-Hydroxymitragynine (7-OH): An Assessment of the Scientific Data and Toxicological Concerns Around an Emerging Opioid Threat
https://www.fda.gov/files/drugs/published/7-hydroxymitragynin_7-oh_an_assessment_of_the_scientific_data_and_toxicological_concerns_around_an_emerging_opioid_threat.pdf (accessed 2026-09-20)
Pharmacokinetics of mitragynine, a major analgesic alkaloid in kratom (Mitragyna speciosa): A systematic review
https://pubmed.ncbi.nlm.nih.gov/31100603/ (accessed 2026-09-20)

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

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