Mitragynine Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

Monoterpenoid indole alkaloid compound Reference needs_revision Best effort · source review pending

Also known as: (-)-Mitragynine, 9-Methoxycorynantheidine, Skf 12711

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Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes

Not standardized / source review pending

Solubility

Reported as soluble in alcohol, chloroform, and acetic acid. Reliable aqueous-solubility data were not established from the authoritative sources reviewed.

Best-Effort Research Profile

Mitragynine is the principal or major indole alkaloid reported in the leaves of Mitragyna speciosa. It has been studied in preclinical and pharmacological research for activity at opioid, adrenergic, serotonergic, and other receptor systems. Mitragynine is chemically distinct from 7-hydroxymitragynine and other Mitragyna alkaloids.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Half-Life

Approximately 3–9 hours in reviewed rat and human pharmacokinetic studies; PubChem cites a rat oral study reporting an elimination half-life of 3.85 hours.

Onset

In reviewed oral pharmacokinetic studies, reported time to maximum plasma concentration was approximately 1.5 hours in rats and humans. A single standardized pharmacodynamic onset value is not established.

Reported Research Effects

Opioid-receptor activity, including interaction with the mu-opioid receptor system
Preclinical antinociceptive or analgesic effects reported in animal and cellular studies
Polypharmacology involving adrenergic, serotonergic, and other receptor systems
Extensive hepatic metabolism and distribution into tissues reported in pharmacokinetic studies

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

Available evidence includes chemical characterization, receptor pharmacology, animal studies, and limited human pharmacokinetic data. Reported pharmacokinetic parameters are study-dependent and should not be treated as universal clinical values. No standardized scientific reference package size or common catalog size was identified from noncommercial authoritative sources; commonSizes is therefore left empty.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

CAS RN: 4098-40-2; PubChem CID: 3034396; molecular formula: C23H30N2O4; molecular weight: 398.5 g/mol; InChIKey: LELBFTMXCIIKKX-QVRQZEMUSA-N; IUPAC name: methyl (E)-2-[(2S,3S,12bS)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate.

Source-Backed Observations

Mitragynine occurs naturally in Mitragyna speciosa, a Southeast Asian plant commonly known as kratom. Reported pharmacology and pharmacokinetics vary substantially with study species, preparation, route, vehicle, and analytical method. It should not be conflated with 7-hydroxymitragynine, a separate and generally less abundant Mitragyna alkaloid.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

(-)-Mitragynine, PubChem Compound Summary CID 3034396
https://pubchem.ncbi.nlm.nih.gov/compound/mitragynine (accessed 2026-09-20)

The Chemical and Pharmacological Properties of Mitragynine and Its Diastereomers: An Insight Review
https://pmc.ncbi.nlm.nih.gov/articles/PMC8907881/ (accessed 2026-09-20)

Pharmacokinetics of mitragynine, a major analgesic alkaloid in kratom (Mitragyna speciosa): A systematic review
https://pubmed.ncbi.nlm.nih.gov/31100603/ (accessed 2026-09-20)

An update on the clinical pharmacology of kratom: uses, abuse potential and future considerations
https://pmc.ncbi.nlm.nih.gov/articles/PMC10846393/ (accessed 2026-09-20)

FDA and Kratom
https://www.fda.gov/news-events/public-health-focus/fda-and-kratom (accessed 2026-09-20)

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.