Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: MOTS-c + SS-31 + Humanin evidence and protocol
Also known as: MOTS/SS31/Humanin
This entry is a multi-compound blend. Each component can be opened individually in the reconstitution calculator.
Component amounts shown are arithmetic starters based on equal distribution. Edit values in the calculator before saving.
MOTS-c + SS-31 + Humanin combines MOTS-c + SS-31 + Humanin into a single research protocol. Each component is independently studied; this entry summarizes the individual evidence base for the combination, since no unified safety/efficacy dataset covers the mixed formulation unless noted below. MOTS-c: Mitochondrial-derived peptide (12S rRNA-encoded) studied for AMPK-linked metabolic regulation and exercise-mimetic effects; preclinical biology well-characterized, zero completed human interventional trials as of 2026. SS-31: Cardiolipin-targeted mitochondrial peptide; FDA-granted accelerated approval (Sept. 2025) as Forzinity (elamipretide) - the first FDA-approved mitochondria-targeted therapeutic - for muscle strength in Barth syndrome. Humanin: 21-amino-acid mitochondria-derived peptide (encoded in 16S rRNA region); binds/activates chemokine receptor CXCR7 and shows cytoprotective, anti-apoptotic, and IAPP-amyloid-blocking chaperone-like activity in research models. This is a community-stacking combination assembled from two independently studied compounds rather than a pharmaceutical sponsor's dedicated fixed-dose combination program - no dedicated human combination trial exists for this exact pairing as of this writing.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Evidence for individual components does not validate the exact mixed formulation. Component amounts, ratios, compatibility, sterility, and stability must be documented.
Supplementary research context only. Not medical advice or a treatment recommendation.
Best-effort summary of forum/Reddit discussion. This is anecdotal community commentary, not a scientific source, and does not count toward this record's verification status. Do not treat it as established fact or medical guidance.
Community dosing guides cover MOTS-c and SS-31/Elamipretide individually (SS-31 described as 'highly regarded in longevity circles' for mitochondrial protection), but Humanin and this specific 3-part combination weren't found discussed as a named stack. Anecdotal only, reflects individual components' reputations rather than this specific blend.
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Community tier-list ranking of mitochondrial/metabolic peptides including MOTS-c and SS-31, based on user-reported experiences; crowd-sourced opinion, not clinically verified.
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Published articles on this site that mention MOTS-c + SS-31 + Humanin or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.