VIP Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: VIP evidence and protocol review

Signal Peptides peptide Lyophilized verified

Also known as: Vasoactive intestinal peptide

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Quick Facts

Reference Sizes

1 mg, 5 mg

Calculator

Preset available

Storage

Lyophilized: store at -20 deg C. After reconstitution: refrigerate 2-8 deg C; verify beyond-use timing against source COA. Note very short half-life/poor stability.

Solubility

Form, salt, and formulation dependent; verify the lot-specific COA

Catalog Description

VIP (Vasoactive Intestinal Peptide) is one of the major peptide transmitters in the central and peripheral nervous systems, involved in vasodilation, anti-inflammatory actions, cell proliferation, hormonal secretion, gastric motility regulation, and smooth muscle relaxation. It shares high sequence homology with PACAP and both bind VPAC1, VPAC2, and PAC1 receptors, activating adenylate cyclase via Gs-protein signaling. Despite decades of research interest, VIP-based drugs are not yet in clinical use, primarily due to poor metabolic stability and poor penetration to target tissue - a significant translational limitation researchers should be aware of.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Rapidly degraded endogenous peptide; protocol depends on route and formulation, so no universal dosing half-life is assigned

Onset

Acute vasodilatory/GI effects reported within minutes in research settings

Administration Routes (Research)

Inhaled and IV in human investigational studies

Reported Research Effects

Vasodilation and anti-inflammatory activity
Regulates gastric motility and smooth muscle relaxation
Shares VPAC1/VPAC2/PAC1 receptor pathway with PACAP
No VIP-based drug has reached clinical use (stability/delivery limitations)

Reported Research Side Effects

Hypotension, flushing, tachycardia, headache, and gastrointestinal effects are mechanistically plausible
The single-dose pulmonary study was small
TESICO did not improve the primary outcome and was stopped for futility
Inhaled and IV protocols are not interchangeable

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

100 mcg inhaled aviptadil as a single dose during right-heart catheterization [Inhaled; 20-person pulmonary-hypertension hemodynamic study; Single dose]Source: PMID 18978135
67 mcg inhaled three times daily for 10 days [Inhaled; Randomized COVID-19 trial protocol; Three times daily]Source: PMID 36127739; NCT04536350
12-hour IV infusion on 3 successive days with targets of 600 pmol/kg on day 1, 1200 pmol/kg on day 2, and 1800 pmol/kg on day 3 [IV; TESICO randomized severe-COVID-19 trial; Daily for 3 days]Source: PMID 37348524; stopped for futility

Research Notes

The record now includes three route- and indication-specific human protocols and the negative TESICO result. No validated SC or CIRS protocol was identified.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

Inhaled aviptadil pulmonary-hypertension study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/18978135/

Inhaled aviptadil randomized COVID-19 protocol — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/36127739/

TESICO IV aviptadil randomized trial — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/37348524/

Inhaled aviptadil COVID-19 study — ClinicalTrials.gov
https://clinicaltrials.gov/study/NCT04536350

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.