Urolithin A Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: Urolithin A evidence and protocol review

Longevity Research compound PowderCapsule verified

Also known as: Urolithin-A

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Quick Facts

Reference Sizes

1 g, 5 g

Storage

No approved consumer storage standard exists for this presentation; follow the lot-specific COA and validated stability data

Solubility

Poorly water-soluble; take with dietary fat

Catalog Description

Urolithin A is a gut-microbial metabolite of dietary ellagitannins and is also administered directly in human studies. A randomized trial in older adults evaluated 500 mg or 1000 mg daily for 4 months and reported mitochondrial biomarker and selected muscle-endurance findings. Separate immune-aging research used its own study design. These studies do not establish disease treatment or longevity extension.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

No single clinically established half-life for oral urolithin A; circulating conjugates and metabolite kinetics vary by formulation and metabolic phenotype

Onset

Muscle and mitochondrial endpoints were assessed over 4 months; immune endpoints are study-specific

Administration Routes (Research)

Oral

Reported Research Effects

Stimulates mitophagy via PINK1/Parkin pathway
Studied for age-related immune decline in RCT
Supports muscle mitochondrial health/function in trials

Reported Research Side Effects

Human safety, pharmacokinetics, and interaction data are incomplete

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

500 mg or 1000 mg once daily [Oral; 4-month randomized older-adult study; Daily]Source: PMID 35050355

Research Notes

Trials show biomarker and selected muscle-endurance signals, not established disease treatment or longevity extension.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

Urolithin A randomized older-adult mitochondrial and muscle trial — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/35050355/

Urolithin A randomized immune-aging trial — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/41174221/

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.