Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: Thymosin Alpha-1 evidence and protocol review
Also known as: TA1, Thymalfasin
Thymosin Alpha-1 (Ta1, thymalfasin) is a 28-amino-acid peptide naturally occurring in the thymus gland, first isolated in 1977 by Allan Goldstein at George Washington University. It exhibits immunomodulatory, anti-inflammatory, and antioxidant properties via stimulation of T-cell differentiation, enhanced thymic output, and modulation of dendritic cell/macrophage activity. It is used clinically (marketed as Zadaxin in 35+ countries, not FDA-approved in the US) for hepatitis B, hepatitis C, as a vaccine-response enhancer, and as an adjunct in sepsis and certain cancers; a systematic review/meta-analysis found it reduced 28-day all-cause mortality in sepsis patients versus placebo, though a separate study found no benefit for restoring CD4+/CD8+ T-lymphocyte counts in COVID-19 patients - reflecting condition-specific evidence rather than uniform efficacy.
Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
1.6 mg twice weekly
Context: commonly studied regimen in chronic-infection and oncology trials
Formulation: Route-specific sterile formulation and professional handling requirements apply; concentration cannot be inferred from an oral or topical product.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
Thymosin alpha-1 is not FDA-approved in the United States; indications and approvals vary internationally. Broad immune-support claims exceed the trial evidence.
Supplementary research context only. Not medical advice or a treatment recommendation.
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Published articles on this site that mention Thymosin Alpha-1 or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.