Thevetia peruviana Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

botanical species; toxic plant containing cardiac glycosides compound Reference needs_revision Best effort · source review pending

Also known as: Cascabela thevetia (L.) Lippold, yellow oleander, lucky nut, be-still, Thevetia neriifolia, Cerbera peruviana

Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes
Not standardized / source review pending
Components
cardiac glycosides, including thevetin A, thevetin B, neriifolin, and related cardenolides + flavonoids and other plant secondary metabolites

Blend Components

This entry is a multi-compound blend. Each component can be opened individually in the reconstitution calculator.

Component
cardiac glycosides, including thevetin A, thevetin B, neriifolin, and related cardenolides
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Component
flavonoids and other plant secondary metabolites
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Component amounts shown are arithmetic starters based on equal distribution. Edit values in the calculator before saving.

Best-Effort Research Profile

Thevetia peruviana (Pers.) K.Schum. is a taxonomic synonym of Cascabela thevetia (L.) Lippold in the Royal Botanic Gardens, Kew Plants of the World Online. The species is native from Mexico through tropical South America and is used as an ornamental plant. Its seeds and other plant parts contain cardiac glycosides and have been associated with digoxin-like poisoning, including gastrointestinal symptoms, bradyarrhythmias, conduction disturbances, dysrhythmias, hyperkalemia, and potentially fatal cardiotoxicity.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Onset
Clinical toxicity after seed ingestion has been reported within approximately 30 minutes in case reports; onset is exposure- and preparation-dependent and no general onset value is established.

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

No standardized dosage, administration regimen, therapeutic route, or validated human pharmacokinetic profile applies to the intact plant species. Published experimental studies concern specific extracts or isolated constituents and should not be generalized to the whole plant. Toxicity data should be interpreted as hazard information, not as a dosing reference.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

Accepted name: Cascabela thevetia (L.) Lippold; synonym: Thevetia peruviana (Pers.) K.Schum.; NCBI Taxonomy ID: 52862; family: Apocynaceae; order: Gentianales; genus: Thevetia in the NCBI taxonomy record and Cascabela in the Kew accepted-name treatment.

Source-Backed Observations

This record refers to a plant species rather than a single purified chemical entity. Chemical composition varies by plant part, provenance, preparation, and extraction method. All parts are considered toxic in the toxicology literature; seeds are particularly documented in poisoning reports. Botanical identity should be recorded with the accepted name and synonym to reduce nomenclatural ambiguity.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

Taxonomy Browser: Thevetia peruviana
https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=52862 (accessed 2026-09-10)
A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander and Thevetia peruviana poisoning
https://pubmed.ncbi.nlm.nih.gov/20438743/ (accessed 2026-09-10)
Acute yellow oleander (Thevetia peruviana) poisoning: cardiac arrhythmias, electrolyte disturbances, and serum cardiac glycoside concentrations on presentation to hospital
https://pubmed.ncbi.nlm.nih.gov/10677410/ (accessed 2026-09-10)
Notes from the Field: Online Weight Loss Supplements Labeled as Tejocote (Crataegus mexicana) Root, Substituted with Yellow Oleander (Cascabela thevetia) — United States, 2022
https://www.cdc.gov/mmwr/volumes/72/wr/pdfs/mm7237a3-h.pdf (accessed 2026-09-10)
Cardiac Glycosides from the Seeds of Thevetia peruviana
https://pubmed.ncbi.nlm.nih.gov/26714048/ (accessed 2026-09-10)

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Related Research Articles

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

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