Substance P Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: Substance P evidence and protocol review

Signal Peptides peptide Lyophilized verified

Also known as: SP peptide

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Quick Facts

Reference Sizes

1 mg, 5 mg

Calculator

Preset available

Storage

Lyophilized: store at -20 deg C. After reconstitution: refrigerate 2-8 deg C; verify beyond-use timing against source COA.

Solubility

Water-soluble lyophilized; reconstitute in sterile water or PBS

Catalog Description

Substance P is an 11-amino-acid neuropeptide of the tachykinin family, acting primarily via the NK1 receptor to transmit pain signals and mediate neurogenic inflammation. It is grouped in the research literature with other neuropeptides (VIP, neurotensin, neurokinin A, secretoneurin, neuropeptide Y) that act on myeloid immune cells, reflecting a broader neuroimmune signaling role beyond its classical pain-transmission function.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Rapidly degraded tachykinin; no therapeutic dosing half-life is established

Onset

Acute pain/inflammatory signaling effects reported within minutes in research settings

Administration Routes (Research)

IV in controlled human physiology research

Reported Research Effects

NK1-receptor-mediated pain signal transmission
Mediates neurogenic inflammation
Acts on myeloid immune cells (neuroimmune signaling)

Reported Research Side Effects

Flushing
Headache provocation
Arterial dilation
Hemodynamic effects
These studies intentionally elicited physiological symptoms and are not therapeutic protocols

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

Successive IV infusions of 0.5, 1.0, 2.0, 4.0, and 8.0 pmol/kg/min in six healthy subjects [IV; Human dose-response physiology study; Sequential escalating infusions]Source: PMID 2425412
1.5 pmol/kg/min by IV infusion for 20 minutes [IV; Double-blind placebo-controlled headache-provocation crossover study; Single infusion]Source: PMID 40369974

Research Notes

The exact human exposures are retained because they are real tested protocols, but both were mechanistic provocation studies rather than treatment research.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

Substance P human infusion dose-response study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/2425412/

Substance P human headache-provocation trial — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/40369974/

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.