Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: PepTools vendor-neutral scientific reference catalog
Also known as: Meridia, Reductil, sibutramine hydrochloride, sibutramine hydrochloride monohydrate
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Sibutramine is a tertiary amino compound and centrally acting anti-obesity agent. Its pharmacologic effects are mediated primarily by active mono- and di-desmethyl metabolites that inhibit norepinephrine and serotonin reuptake and, to a lesser extent, dopamine reuptake. The parent drug was formerly marketed in the United States as Meridia and in Europe as Reductil and related names. The U.S. approval was withdrawn on December 21, 2010, and European marketing authorisations were suspended in 2010 following safety evaluations concerning cardiovascular events.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Historical clinical-reference dosing in the FDA label was 5, 10, or 15 mg once daily, with 10 mg as the labeled starting dose and doses above 15 mg/day not recommended. These values are provided only as historical study and labeling information, not as current treatment guidance. FDA requested voluntary U.S. market withdrawal in October 2010, and approval was withdrawn on December 21, 2010. EMA concluded in 2010 that the benefits of sibutramine-containing medicines did not outweigh their risks and recommended suspension of European marketing authorisations.
Supplementary research context only. Not medical advice or a treatment recommendation.
CAS RN 106650-56-0; PubChem CID 5210; molecular formula C17H26ClN; molecular weight 279.8 g/mol; IUPAC name 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine; InChIKey UNKXFIYQGJQOQW-UHFFFAOYSA-N
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Published articles on this site that mention sibutramine or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.