Ribupatide Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

Investigational dual GLP-1/GIP receptor agonist peptide compound Reference needs_revision Best effort · source review pending

Also known as: HRS9531, KAI-9531

Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes
Not standardized / source review pending

Best-Effort Research Profile

Ribupatide is an investigational dual GLP-1/GIP receptor agonist developed for research in obesity and type 2 diabetes. Preclinical studies reported activity at both receptor pathways, subcutaneous bioavailability in animal models, and reductions in body weight and food intake in diet-induced obese mice. First-in-human evaluation reported subcutaneous administration, pharmacokinetic properties compatible with once-weekly dosing, and a mean half-life of approximately 7–8 days in the multiple-ascending-dose study.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Half-Life
Mean half-life approximately 7–8 days across the multiple-ascending-dose range in the reported first-in-human subcutaneous study.
Administration Routes (Research)
subcutaneousoral

Reported Research Effects

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

Evidence-backed study regimens: the first-in-human study evaluated single subcutaneous doses of 0.1, 0.3, 0.9, 2.7, 5.4, and 8.1 mg, and multiple subcutaneous dosing of 0.9, 2.7, and 5.4 mg once weekly for 4 weeks, including a 2.7/2.7/4.0/5.4 mg escalation sequence. A 2026 American Diabetes Association conference abstract reported oral ribupatide doses of 10, 25, or 50 mg for 26 weeks in adults with obesity without diabetes. These are clinical-study regimens and not prescribing or self-administration guidance. Ribupatide remains an investigational compound in the cited records.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

International Nonproprietary Name (INN): ribupatide; development codes: HRS9531 and KAI-9531; ClinicalTrials.gov identifier for first-in-human study: NCT05152277; DOI: 10.1111/dom.71218

Source-Backed Observations

Ribupatide is a chemically synthesized peptide/polypeptide. The WHO proposed INN publication provides a peptide chemical description. Public clinical research records identify both injectable and oral development programs. No common commercial or catalog reference size was established from authoritative scientific sources.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

Preclinical and First-In-Human Evaluation of Ribupatide (HRS9531), a Dual GLP-1/GIP Receptor Agonist
https://pubmed.ncbi.nlm.nih.gov/42764407/ (accessed 2026-09-30)
A Trial of Ribupatide Injection in Participants With Obesity and Knee Osteoarthritis, NCT07709910
https://clinicaltrials.gov/study/NCT07709910 (accessed 2026-09-30)
Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes, NCT07284875
https://clinicaltrials.gov/study/NCT07284875 (accessed 2026-09-30)

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Related Research Articles

Published articles on this site that mention Ribupatide or one of its catalog aliases.

Related Research Tools

Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

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