Rapamycin Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: Rapamycin evidence and protocol review

Longevity Research compound TabletOral solutionPowder needs_revision Best effort · source review pending

Also known as: Sirolimus

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Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes

100 mg, 500 mg

Storage

No approved consumer storage standard exists for this presentation; follow the lot-specific COA and validated stability data

Solubility

Poorly water-soluble; dissolve in ethanol then dilute; compounded oral preparations available for research

Best-Effort Research Profile

Rapamycin (sirolimus) is an mTOR inhibitor, FDA-approved as an immunosuppressant (Rapamune) for organ transplant rejection prevention. In mouse studies, rapamycin has extended lifespan by up to 28% and improved multiple age-related indicators (muscle strength, immune function, mitochondrial function, cardiovascular and brain health). The PEARL trial (a human healthspan-metrics study) reported safety and efficacy results after one year of low-dose intermittent rapamycin in a preprint posted 2024; longevity-focused human trial data remains earlier-stage than the extensive mouse-model evidence base. Off-label longevity use should be distinguished from its approved transplant-immunosuppression indication and dosing.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Half-Life

~57-63 hours (per approved product labeling)

Onset

Mouse lifespan studies run the animal's full lifespan; PEARL human trial assessed at 1 year

Administration Routes (Research)

Oral

Reported Research Effects

mTOR inhibition
Extends lifespan up to 28% in mouse studies
Improves multiple age-related health indicators in mice
PEARL trial: human healthspan-metrics data reported (2024 preprint)

Reported Research Side Effects

Human safety, pharmacokinetics, and interaction data are incomplete

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

Use the indication- and trough-guided regimen in the selected sirolimus product [Oral; Ongoing with therapeutic monitoring; Once daily]Source: RAPAMUNE prescribing information

Research Notes

Rapamycin is sirolimus. Longevity dosing is unapproved and no evidence-based consumer anti-aging protocol exists; immunosuppression, infection, malignancy, metabolic, pulmonary, and wound-healing risks are material.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources Under Review

RAPAMUNE sirolimus prescribing information — DailyMed (NIH)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3275b824-3f82-4151-2ab2-0036a9ba0acc

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.