PQQ Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PQQ evidence and protocol review

Longevity Research compound PowderCapsule needs_revision Best effort · source review pending

Also known as: Pyrroloquinoline quinone

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Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes

100 mg, 500 mg

Storage

Use the disodium-salt finished-product specification; do not assume equivalence across PQQ forms

Solubility

Water-soluble as PQQ disodium salt

Best-Effort Research Profile

Pyrroloquinoline quinone (PQQ) is a redox-active compound studied for its role in supporting mitochondrial biogenesis via PGC-1alpha signaling pathways, alongside direct antioxidant properties. It is often studied or supplemented alongside CoQ10 given complementary proposed mechanisms (biogenesis vs. direct electron-transport support).

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Half-Life

No broadly accepted clinical half-life supporting a universal dosing interval

Onset

Mitochondrial biogenesis effects studied over weeks in preclinical models; human data more limited

Administration Routes (Research)

Oral

Reported Research Effects

Studied for mitochondrial biogenesis support (PGC-1alpha pathway)
Antioxidant properties

Reported Research Side Effects

Small sample size
Sponsor/formulation specificity
Human long-term safety and clinically meaningful outcome evidence remain limited

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Route-Specific Research Protocols

Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.

Label / guideline Human study Community only Preclinical only Not established

Oral Human study only

20 mg PQQ disodium salt orally once daily for 12 weeks

Frequency / timing: Daily
Duration / setting: Randomized double-blind placebo-controlled study in 41 healthy older adults
Technique: Oral
Evidence: Human study protocol

Context: PMID 26782228

Formulation: Oral-mucosal formulations are not dose-equivalent to injectable or topical formulations.

Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.

Source 1

Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.

Research Notes

This row now identifies the tested salt, sample size, dose, and duration. It does not generalize the findings to injectable PQQ or other chemical forms.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources Under Review

PQQ disodium salt randomized cognition study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/26782228/

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.