PNC-27 Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: p53-HDM2 targeting and membrane-active oncology research

Oncology Research peptide LyophilizedPowder verified

Also known as: p53-HDM2 membrane-active peptide

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Quick Facts

Reference Sizes

30 mg

Storage

Use lot-specific analytical and stability documentation

Solubility

Form and salt dependent; verify against the analytical certificate

Catalog Description

PNC-27 is a chimeric peptide containing a p53-derived HDM2-binding segment and a membrane-penetrating segment. Published evidence is preclinical and includes cancer-cell lysis experiments and a mouse acute-myeloid-leukemia model.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Not established in human pharmacokinetic studies

Onset

Study-dependent; no validated human onset

Administration Routes (Research)

In vitroIP in mice; human route not established

Reported Research Effects

Membrane pore formation in selected cancer-cell models
Tumor-response findings in mice
No human clinical efficacy

Reported Research Side Effects

No human safety profile; high-dose animal and cell findings cannot be translated directly to people.

Data source: Primary literature and authoritative identity records

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

50 ug/mL [In vitro cancer-cell exposure; 0-3 hours; Continuous exposure]Source: mechanistic cell study
40 mg/kg daily [IP; 2-3 weeks in mice; Once daily]Source: AML mouse-model study PMID 31337857

Research Interactions

Flagged Avoid / Caution Combinations (Research)

Unvalidated combinations

Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.

Research Notes

Cross-reference catalog inclusion confirmed; sales-page dosing was not promoted to a verified protocol without traceable primary evidence.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

PNC-27 cancer-cell membrane mechanism — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/20182728/

PNC-27 in an AML mouse model — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/31337857/

PNC-27 mechanistic review — PubMed Central (NIH)
https://pmc.ncbi.nlm.nih.gov/articles/PMC9138867/

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.