Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: PepTools vendor-neutral scientific reference catalog
Also known as: ZP8396, RO7895515
Petrelintide is a synthetic peptide analogue of human amylin with agonistic activity at amylin receptors AMY1 and AMY3 and activity at the calcitonin receptor relative to human calcitonin. Its fatty-acyl modification promotes reversible albumin binding and prolonged systemic exposure. Human phase 1 studies evaluated subcutaneous and intravenous administration, with subsequent development focused on once-weekly subcutaneous dosing.
Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Phase 1 studies evaluated single subcutaneous doses of 0.04–2.4 mg and a single 0.35 mg intravenous dose. Multiple-ascending-dose studies evaluated once-weekly subcutaneous dosing at 0.6 and 1.2 mg for 6 weeks, and dose-escalation regimens targeting 2.4, 4.8, or 9.0 mg over 16 weeks. These are study regimens recorded for research reference only and are not prescribing or administration recommendations. ClinicalTrials.gov records identify ZP8396 as petrelintide and document ongoing clinical evaluation, including once-weekly subcutaneous administration.
Supplementary research context only. Not medical advice or a treatment recommendation.
Molecular formula: C185H305N49O61; approximate molecular mass: 4.2 kDa; WHO Recommended INN: petrelintide; PubChem CID: 172915807; development code: ZP8396; Roche development code: RO7895515.
Petrelintide is an investigational compound and is not represented here as an approved or marketed medicine. WHO documentation describes the 37-residue peptide structure, its 19-carboxynonadecanoyl modification, and an intramolecular amide bridge between Asp4 and Lys6. PubChem also lists a ZP8396-related record with a different molecular formula; the WHO Recommended INN record and current PubChem petrelintide record support C185H305N49O61 for petrelintide itself.
Reflects published research. Educational reference — not a recommendation for use.
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Published articles on this site that mention Petrelintide or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.