Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: PE-22-28 evidence and protocol review
Also known as: PE 22 28
PE-22-28 is a synthetic 7-residue peptide (spanning residues 22-28 of spadin), engineered as a shortened, optimized analog of spadin - a 17-residue endogenous antidepressant peptide cleaved from the propeptide of sortilin (SORT1 gene) during Golgi processing. PE-22-28 achieves substantially better TREK-1 potassium channel binding affinity and specificity than spadin itself (IC50 0.12nM vs. 40-60nM), along with extended duration of action (up to 23 hours) and improved in vivo stability. TREK-1 is a two-pore-domain potassium channel abundant in hippocampal and cortical neurons, regulating neuronal excitability relevant to mood and cognition. Rodent behavioral studies show antidepressant-like effects and enhanced hippocampal neurogenesis with PE-22-28, but no completed, published human efficacy trials existed as of April 2026 - the evidence base remains entirely preclinical.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
The 400 mcg intranasal schedule was unsupported community guidance.
Supplementary research context only. Not medical advice or a treatment recommendation.
Best-effort summary of forum/Reddit discussion. This is anecdotal community commentary, not a scientific source, and does not count toward this record's verification status. Do not treat it as established fact or medical guidance.
Community discussion of PE-22-28 (an experimental antidepressant/anhedonia-focused peptide) includes both self-reported positive experiences and general skepticism about wasted time/money on unproven compounds. Anecdotal, not clinically verified in humans.
User shares a first-hand trial report of PE-22-28, describing subjective mood/anhedonia effects; single self-reported account.
Community thread collecting multiple self-reported experiences with PE-22-28 for anhedonia, with mixed results reported across users.
Found a relevant Reddit or forum thread about this compound? Suggest it below. Every suggestion is reviewed by an editor before it appears -- nothing is published automatically.
Published articles on this site that mention PE-22-28 or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.