PDRN Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PDRN evidence and protocol review

Cosmetic Research polynucleotide PowderLiquid verified

Also known as: Polydeoxyribonucleotide

Open in Calculator ← Compound Index All Tools

Quick Facts

Reference Sizes

100 mg, 500 mg, 1 g

Storage

Use product-specific sterile ampule labeling; heterogeneous source-derived material requires lot and manufacturer controls

Solubility

Water-soluble; injectable aqueous solution

Catalog Description

PDRN (Polydeoxyribonucleotide) is a mixture of deoxyribonucleotide fragments (commonly derived from salmon or trout sperm/testes DNA) with documented regenerative and anti-inflammatory properties across wound-healing, periodontal-regeneration, and post-procedure aesthetic-recovery applications. Its primary mechanism is selective activation of the A2A adenosine receptor and induction of the phosphate-scavenger system, overlapping with skin-regeneration processes following surgical procedures - supporting its use alongside laser resurfacing, chemical peeling, microneedling, and radiofrequency treatments. A systematic review of periodontal regeneration found significant improvements in clinical attachment level, bone fill, and probing-depth reduction versus controls; reviewers note a continued need for more RCTs with human aesthetic cohorts and longer follow-up.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

No single clinically validated half-life for heterogeneous PDRN mixtures; do not treat PDRN as one defined oligonucleotide

Onset

Regenerative effects assessed over weeks in wound-healing and periodontal studies

Administration Routes (Research)

IM plus perilesional in wound trialsLocal injection in plantar-fasciitis research

Reported Research Effects

A2A adenosine receptor activation drives regenerative/anti-inflammatory effects
Promotes cell migration, growth, and angiogenesis in wound-healing models
Significant clinical attachment level/bone fill improvements in periodontal regeneration (systematic review)

Reported Research Side Effects

No adverse effect reported during the small pressure-ulcer trial
Injection pain, bleeding, infection, and hypersensitivity remain route-related concerns
Source species, molecular-size distribution, and product purification are clinically relevant

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

5.625 mg in 3 mL IM five days per week for 2 weeks plus 5.625 mg in 3 mL perilesionally twice per week for 2 weeks [IM plus perilesional; Randomized diabetic-foot-ulcer study between surgeries; Scheduled injections]Source: PMID 29076318
5.625 mg in 3 mL IM five days per week for 2 weeks plus 5.625 mg in 3 mL perilesionally twice per week for 4 weeks [IM plus perilesional; Randomized pressure-ulcer study; Scheduled injections]Source: PMID 25473213
Weekly local injections for 3 weeks [Local injection; Randomized plantar-fasciitis study; Weekly]Source: PMID 25920599; abstract does not report the injected milligram amount

Research Notes

PDRN is a mixture of DNA-derived fragments, not a single peptide. The exact wound-study injections are now recorded separately; they do not validate generalized aesthetic or systemic-wellness injection schedules.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

PDRN randomized diabetic-foot-ulcer study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/29076318/

PDRN randomized pressure-ulcer study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/25473213/

PDRN plantar-fasciitis randomized trial — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/25920599/

Suggest a community source

Found a relevant Reddit or forum thread about this compound? Suggest it below. Every suggestion is reviewed by an editor before it appears -- nothing is published automatically.

Related Research Tools

Reconstitution CalculatorConcentration, draw volume, per-unit amounts Unit Convertermg, mcg, mL, units conversion Compound CompareSide-by-side comparison tool Cost CalculatorCost per mg, mcg, per-draw

Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.