Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: PACAP-38 evidence and protocol review
Also known as: Pituitary adenylate cyclase-activating peptide 38
PACAP-38 is the longer and more abundant (approximately 90% of total PACAP) isoform of Pituitary Adenylate Cyclase-Activating Polypeptide, sharing the same VPAC1/VPAC2/PAC1 receptor pathway, Gs-protein/adenylate cyclase signaling mechanism, and high sequence homology with VIP as PACAP-27. It has been studied in migraine research as a trigger compound in provocation studies, distinguishing it somewhat from the shorter isoform's primary research contexts.
Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
10 pmol/kg/min by IV infusion for 20 minutes
Context: PMID 40229719
Formulation: Route-specific sterile formulation and professional handling requirements apply; concentration cannot be inferred from an oral or topical product.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
PACAP-38 has been administered to humans primarily as a mechanistic migraine-provocation tool. The exact tested infusion is retained because it is a real human protocol, but it should never be framed as a wellness or treatment regimen.
Supplementary research context only. Not medical advice or a treatment recommendation.
Found a relevant Reddit or forum thread about this compound? Suggest it below. Every suggestion is reviewed by an editor before it appears -- nothing is published automatically.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.