PACAP-27 Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PACAP-27 evidence and protocol review

Signal Peptides peptide Lyophilized Community-Supported (not scientifically verified)

Also known as: Pituitary adenylate cyclase-activating peptide 27

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Community-Supported: unlocked based on forum/Reddit discussion, NOT on peer-reviewed or scientific verification. This content is for research and educational reference only. These compounds, protocols, and dosing figures are not verified, may not be FDA-approved, and are not intended for use in humans or animals. Always independently verify before relying on any of this information.

Quick Facts

Reference Sizes
1 mg
Calculator
Preset available
Storage
Lyophilized: store at -20 deg C. After reconstitution: refrigerate 2-8 deg C; verify beyond-use timing against source COA.
Solubility
Lyophilized; reconstitute in sterile water or PBS; water-soluble

Catalog Description

PACAP-27 is the shorter (27-amino-acid) isoform of Pituitary Adenylate Cyclase-Activating Polypeptide, sharing high sequence homology with VIP and binding the same VPAC1, VPAC2, and PAC1 receptors to activate adenylate cyclase via Gs-protein signaling. Like VIP, it has documented effects modulating biochemical pathways in immune (leukemic myeloid) cells, but translational drug development faces similar metabolic-stability challenges.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life
Very short (minutes; rapid enzymatic degradation, similar to VIP)
Onset
Acute effects reported within minutes in research settings
Administration Routes (Research)
SC/IV (research use)

Reported Research Effects

Reported Research Side Effects

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

Research Notes

PACAP can produce potent vasodilatory and headache effects; animal doses are not human protocols.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

PubMed literature search: PACAP-27 peptide animal study neuroprotection — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/?term=PACAP-27%20peptide%20animal%20study%20neuroprotection

Community Discussion Unverified

Best-effort summary of forum/Reddit discussion. This is anecdotal community commentary, not a scientific source, and does not count toward this record's verification status. Do not treat it as established fact or medical guidance.

r/migrainescience - PACAP research summary
https://www.reddit.com/r/migrainescience/comments/1bbkdmj/becaus_it_seems_one_of_the_lectures_has_made/

Community-written summary of PACAP research discussed after a migraine science lecture; anecdotal/community synthesis, not scientific verification.

r/migraine - PACAP is 'the new' CGRP (Nature article discussion)
https://www.reddit.com/r/migraine/comments/1ob2l2g/nature_article_about_migraines_drug_history_pacap/

Community discussion of a Nature article on PACAP-targeted migraine drug development; anecdotal only.

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Related Research Tools

Reconstitution CalculatorConcentration, draw volume, per-unit amounts Unit Convertermg, mcg, mL, units conversion Compound CompareSide-by-side comparison tool Cost CalculatorCost per mg, mcg, per-draw

Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

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