P21 Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: P21 evidence and protocol review

Neuro Research peptide Lyophilized verified

Also known as: P021, P21 peptide

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Quick Facts

Reference Sizes

2 mg, 5 mg, 10 mg

Calculator

Preset available

Storage

Use source-label storage wording. Track lot, storage location, and open/reconstitution date.

Solubility

Lyophilized; reconstitute in sterile water for SC; saline for intranasal

Catalog Description

P21 is a peptide derived from p21 (Cip1/Waf1), a cyclin-dependent kinase inhibitor protein, studied in rodent models for effects on neuroinflammation, synaptic plasticity, and cognitive function. In aged Fischer rats, P21 counteracted age-related declines in learning and memory, reportedly by restoring hippocampal and cortical neurogenesis and upregulating brain-derived neurotrophic factor (BDNF) signaling. Separate preclinical work in 3xTg-AD transgenic mice found P21 attenuated tau and, to a lesser extent, amyloid-beta pathology, with effects proposed to act through the BDNF/TrkB/PI3-K/AKT/GSK3-beta pathway. All available evidence is preclinical (rodent); no human clinical trials have been published, and mechanistic details (specific receptor targets, optimal dosing, exposure route) remain incompletely characterized.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Not characterized in humans; adamantylated glycine was added to improve stability and blood-brain-barrier exposure

Onset

Cognitive/behavioral effects measured over weeks of repeated dosing in rodent studies

Administration Routes (Research)

Oral dietary exposure in mouse studies; no validated human or SC route

Reported Research Effects

Reversal of age-related learning/memory decline in aged rat models
Attenuation of tau pathology in 3xTg-AD mouse model
Reported BDNF/TrkB pathway upregulation
Preclinical reduction of neuroinflammatory markers

Reported Research Side Effects

No human safety profile
Long-duration dietary mouse exposures do not establish injectable dosing
Developmental and neurotrophic effects require disease-model and life-stage context

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

60 nmol P021 per gram of feed from age 3 months through age 21 months; mice consumed about 2.7 g feed/day, approximately 162 nmol P021 per mouse per day [Oral dietary exposure; 3xTg-AD mouse prevention study; Daily in feed]Source: PMID 28655344
60 nmol P021 per gram of formulated diet for 70 days beginning at postnatal day 21 [Oral dietary exposure; CDKL5-knockout mouse study; Daily in feed]Source: PMID 39592934
P021-containing diet for 12 months beginning at age 9-10 months [Oral dietary exposure; 3xTg-AD mouse disease-modification study; Daily in feed]Source: PMID 25046994

Research Notes

The catalog name P21 is often used for P021, the CNTF-derived peptidergic compound Ac-DGGL(A)G-NH2. All located dosing evidence is preclinical and oral-in-feed; no human or injectable protocol was found.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

P021 long-term 3xTg-AD mouse prevention study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/28655344/

P021 CDKL5-deficiency mouse study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/39592934/

P021 chronic 3xTg-AD mouse treatment study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/25046994/

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.