Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: PepTools vendor-neutral scientific reference catalog
Also known as: NPL 20
NPL20 is the study code for a lead ionizable N-alkyl phosphoramidate lipid reported in a 2026 Advanced Science study. The molecule incorporates a tertiary amine, an additional dodecyl-derived N-alkyl hydrophobic tail, and branched O-alkyl hydrophobic tails. It was investigated as the ionizable lipid component of lipid nanoparticles for localized messenger RNA delivery to inguinal white adipose tissue in mice.
Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
NPL20 is a study-designated lipid rather than a standardized, independently indexed compound with a complete public chemical identifier set. The reviewed primary report describes its structural class and functional design but does not provide sufficient openly accessible information to reliably assign a full systematic name, molecular formula, molecular weight, solubility, half-life, or standalone storage specification. Common reference sizes are not an appropriate scientific/catalog fact for this research lipid and are therefore omitted.
Supplementary research context only. Not medical advice or a treatment recommendation.
Study code: NPL20. No CAS Registry Number, standardized chemical name, molecular formula, InChI, or InChIKey was reported in the authoritative sources reviewed.
The reported apparent pKa for NPL20 was 7.78. The authors describe NPL20 as an N-alkyl phosphoramidate lipid with a dodecyl-modified amine and degradable branched O-alkyl hydrophobic tails. Lead-candidate structures were characterized by NMR and mass spectrometry, with reported LC-MS purities above 90%.
Reflects published research. Educational reference — not a recommendation for use.
Found a relevant Reddit or forum thread about this compound? Suggest it below. Every suggestion is reviewed by an editor before it appears -- nothing is published automatically.
Published articles on this site that mention NPL20 or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.