neriifolin Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

cardenolide glycoside compound Reference needs_revision Best effort · source review pending

Also known as: Digitoxigenin 3-(alpha-L-thevetoside), CAS 466-07-9

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Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes

Not standardized / source review pending

Best-Effort Research Profile

Neriifolin is a cardenolide glycoside consisting of digitoxigenin glycosylated at the 3-position with a 6-deoxy-3-O-methyl-alpha-L-glucopyranoside residue. ChEBI records its occurrence in Cerbera and Thevetia species and classifies it as a cardenolide glycoside with toxin, cardiotonic-drug, neuroprotective-agent, and cardioprotective-agent roles. Experimental studies have examined its cardiac electrophysiology, toxicity, and cellular effects; these findings are primarily preclinical or case-associated.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Half-Life

19.2 hours reported as a calculated serum biological half-life in a 2025 Cerbera odollam poisoning case-analysis study; context-specific.

Reported Research Effects

Cardiac glycoside and cardenolide activity; cardiac glycosides are associated with Na+/K+-ATPase inhibition as a class mechanism.
Concentration-dependent electrophysiological disturbance and pro-arrhythmic activity in human iPSC-derived cardiomyocytes in vitro.
Complete beat arrest of spontaneously beating human iPSC-derived cardiomyocytes at 300 nM in one in-vitro study.
Cellular preclinical studies have reported endoplasmic-reticulum-stress-associated DNA damage and apoptosis in prostate cancer models.

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

No reliable authoritative source identified for a standardized reference solubility, storage condition, onset, administration route, or catalog size. Evidence for biological effects includes in-vitro studies and poisoning-case analytical data; no standardized human research dosing regimen was established from the reviewed authoritative sources.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

PubChem CID 441867; ChEBI CHEBI:7522; CAS 466-07-9; KEGG C08876; ChEMBL CHEMBL501533; LIPID MAPS LMST01120021; molecular formula C30H46O8; average molecular mass 534.690 g/mol; monoisotopic mass 534.31927 Da; InChIKey VPUNMTHWNSJUOG-BAOINKAISA-N

Source-Backed Observations

Neriifolin is a toxic cardiac glycoside. In a human induced-pluripotent-stem-cell-derived cardiomyocyte microelectrode-array study, it produced concentration-dependent pro-arrhythmic effects and complete beat arrest at 300 nM. A 2025 LC-MS/MS case-analysis study reported a calculated serum biological half-life of 19.2 hours in the context of Cerbera odollam poisoning; this value should not be generalized as an established pharmacokinetic parameter for other contexts.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

Neriifolin | CID 441867
https://pubchem.ncbi.nlm.nih.gov/compound/Neriifolin (accessed 2026-09-10)

Investigation of cardiac glycosides from oleander in a human induced pluripotent stem cells derived cardiomyocyte model
https://pubmed.ncbi.nlm.nih.gov/34371141/ (accessed 2026-09-10)

Cardiac glycoside neriifolin exerts anti-cancer activity in prostate cancer cells by attenuating DNA damage repair through endoplasmic reticulum stress
https://pubmed.ncbi.nlm.nih.gov/36792037/ (accessed 2026-09-10)

Development of an LC-MS/MS detection method for cardiac glycosides (cerberin, neriifolin, and tanghinin) in human blood serum: Application to a Cerbera odollam poisoning case
https://www.sciencedirect.com/science/article/pii/S0731708525003541 (accessed 2026-09-10)

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.