Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: Methionine evidence and protocol review
Also known as: L-Methionine
Methionine is an essential amino acid and the precursor to S-adenosylmethionine (SAMe), the body's principal methyl donor for DNA, protein, and neurotransmitter methylation reactions. It is also a precursor in the transsulfuration pathway leading to cysteine and glutathione synthesis.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
500 mg
Context: Randomized placebo-controlled crossover study in women with chronic urinary tract infection and healthy controls
Formulation: Oral-mucosal formulations are not dose-equivalent to injectable or topical formulations.
Route safety: Study exposure, not a general supplementation recommendation. Plasma homocysteine increased during supplementation.
1 g twice daily (phase 1); 2 g twice daily (phase 2)
Context: Randomized controlled hot-flash study in postmenopausal women
Formulation: Oral study product; participants also received folate and methylcobalamin.
Route safety: Study exposure, not a general supplementation recommendation. Methionine raised serum homocysteine despite co-supplementation.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
Methionine is essential, but excess isolated intake can raise homocysteine depending on folate, B12, and B6 status. Acetaminophen-antidote use outside the U.S. is a separate drug context.
Supplementary research context only. Not medical advice or a treatment recommendation.
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Published articles on this site that mention Methionine or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.