Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: Matrixyl Synthe'6 evidence and protocol review
Also known as: Palmitoyl tripeptide-38
This entry is a multi-compound blend. Each component can be opened individually in the reconstitution calculator.
Component amounts shown are arithmetic starters based on equal distribution. Edit values in the calculator before saving.
Matrixyl Synthe'6 is a newer-generation signal-peptide formulation in the Matrixyl product family, sharing the core mechanistic concept (dermal fibroblast collagen-signaling stimulation) with the original Palmitoyl Pentapeptide-4/Matrixyl 3000, but as a distinct, more recently developed formulation it has a smaller independent clinical-trial evidence base of its own compared to the well-documented 2005 Robinson et al. RCT for the original compound.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
The 2% figure refers to a commercial carrier raw material, not 2% pure palmitoyl tripeptide-38. Independent randomized clinical replication was not located. Commercial citation removed; no neutral primary or regulatory source was located in this audit. Commercial formulation directions were removed and are not treated as a validated research protocol.
Supplementary research context only. Not medical advice or a treatment recommendation.
Best-effort summary of forum/Reddit discussion. This is anecdotal community commentary, not a scientific source, and does not count toward this record's verification status. Do not treat it as established fact or medical guidance.
Reddit skincare/tretinoin communities report layering Timeless' Matrixyl Synthe'6 serum alongside tretinoin without noted interactions (it's Palmitoyl-based with no copper, so no expected Vitamin C conflict). Users describe it as more hydrating and 'preventative' compared to Matrixyl 3000, which they position as better suited for visible/current aging concerns. This is anecdotal community experience only -- no clinical citation was located during this review.
Multiple users report daily co-use with tretinoin with no issues; describe Synthe'6 as more hydrating/preventative vs Matrixyl 3000 for active aging concerns.
General community roundup of popular cosmetic signal peptides used for skin/anti-aging; covers this peptide class broadly. Crowd-sourced, not clinically verified.
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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.