L-Histidine Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: L-Histidine evidence and protocol review

Amino Acids & Nutrients amino-acid PowderCapsule verified

Also known as: Histidine

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Quick Facts

Reference Sizes

10 g, 100 g

Storage

No approved consumer storage standard exists for this presentation; follow the lot-specific COA and validated stability data

Solubility

Freely water-soluble as HCl salt

Catalog Description

L-histidine is an essential amino acid, serving as the precursor to histamine (via decarboxylation) and a structural component of carnosine (with beta-alanine). It plays roles in hemoglobin synthesis, tissue repair, and metal-ion chelation (as a component of many metalloenzymes).

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Not applicable in typical drug-PK sense (essential amino acid)

Onset

N/A - dietary/supplemental repletion studied over weeks

Administration Routes (Research)

Oral

Reported Research Effects

Precursor to histamine and carnosine
Role in hemoglobin synthesis and tissue repair

Reported Research Side Effects

Human safety, pharmacokinetics, and interaction data are incomplete

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

4 g/day [Oral; 12 weeks; Daily]Source: randomized trial in women with metabolic syndrome
3.5 g/day [Oral; 4 weeks; Daily]Source: muscle-carnosine study

Research Notes

These are study-specific regimens, not a general supplement recommendation. The 2026 single-dose trial missed superiority in the prespecified overall population and reported only exploratory subgroup findings.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

Histidine randomized metabolic-syndrome trial — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/23361591/

Histidine and muscle carnosine study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/28106620/

Single-dose histidine fatigue trial — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/41986440/

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.