Kybella Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

Prescription cytolytic injectable; deoxycholic acid compound Reference needs_revision Best effort · source review pending

Also known as: deoxycholic acid injection, deoxycholic acid, ATX-101

Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes
Not standardized / source review pending
Storage
Store at 20°C to 25°C (68°F to 77°F); permitted excursions are 15°C to 30°C (59°F to 86°F). Each vial is for single-patient use.

Best-Effort Research Profile

Kybella contains synthetic deoxycholic acid, a naturally occurring bile acid. When injected into submental fat, deoxycholic acid physically disrupts cell membranes and causes cytolysis. The FDA-approved product is a clear, colorless, sterile 10 mg/mL solution supplied in 2 mL single-use vials containing 20 mg of deoxycholic acid.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Onset
Rapid absorption; after a labeled maximum single-treatment dose of 100 mg, median plasma Tmax was 18 minutes. Plasma deoxycholic acid levels returned to the endogenous range within 24 hours in the FDA pharmacokinetic assessment.
Administration Routes (Research)
subcutaneous

Reported Research Effects

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

FDA-labeled administration uses an area-adjusted dose of 2 mg/cm², with each injection containing 2 mg in 0.2 mL and spaced 1 cm apart; a single treatment may include up to 50 injections and 100 mg total in up to 10 mL. Up to 6 treatments may be administered at intervals of at least 1 month. In phase III randomized placebo-controlled studies of ATX-101, investigational regimens included 1 or 2 mg/cm² injected into submental fat for up to 4 treatment sessions approximately 28 days apart. These details are provided as neutral study/reference information and are not individualized treatment instructions.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

Chemical name: 3α,12α-dihydroxy-5β-cholan-24-oic acid; molecular formula: C24H40O4; molecular weight: 392.57 g/mol; UNII: 005990WHZZ; RxCUI: 1649980 for Kybella 20 mg in 2 mL injection; NDC package identifiers include 61168-101-01, 61168-101-03, and 61168-101-04.

Source-Backed Observations

The FDA label identifies injection-site edema or swelling, hematoma, pain, numbness, erythema, and induration as common adverse reactions. The product is contraindicated in the presence of infection at the injection area. Use outside the submental region is not approved or recommended in the FDA labeling.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

KYBELLA (deoxycholic acid) injection, Prescribing Information, Revised September 2026
https://www.accessdata.fda.gov/drugsatfda_docs/label/2026/206333s007lbl.pdf (accessed 2026-09-25)
KYBELLA- deoxycholic acid injection, solution: Structured Product Label
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fe431ed4-ea6f-4e99-b4bc-ec25ae7b8553 (accessed 2026-09-25)
Reduction of unwanted submental fat with ATX-101 (deoxycholic acid), an adipocytolytic injectable treatment: results from a phase III, randomized, placebo-controlled study
https://pubmed.ncbi.nlm.nih.gov/24147933/ (accessed 2026-09-25)

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

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