Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: Klotho animal cognition evidence
Also known as: Alpha-Klotho
Klotho is a protein (membrane-bound and secreted forms) originally identified through a mouse mutant with accelerated aging phenotype; the secreted form functions as a hormone-like regulator of FGF23/phosphate signaling and has anti-oxidative, anti-fibrotic properties studied in kidney, cardiovascular, and cognitive aging research. It remains primarily a research/biomarker target rather than an approved or widely available therapeutic peptide.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary mouse and nonhuman-primate studies
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.
Peripheral Klotho improved cognition in mice and aged rhesus macaques, but no controlled human administration trial establishes a therapeutic dose or safety profile.
Supplementary research context only. Not medical advice or a treatment recommendation.
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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.