Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: kisspeptin-10 reproductive physiology
Also known as: KP-10, Metastin 45-54
Kisspeptin-10 (KP-10) is the bioactive C-terminal decapeptide fragment of kisspeptin-54, acting on GPR54 (KISS1R) receptors to stimulate hypothalamic GnRH pulsatility and downstream LH/FSH release. Human studies report a sexually dimorphic response: KP-10 stimulates gonadotropin release in men and in women during the preovulatory phase, but fails to do so in women during the follicular phase. A direct comparison trial found intravenous kisspeptin-10 and kisspeptin-54 produced similar gonadotrophin secretion in healthy men, though native GnRH was more potent than either kisspeptin isoform - kisspeptin may nonetheless act more physiologically than direct GnRH-receptor agonists.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary human dose-response and continuous-infusion studies
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
0.01-3 mcg/kg as single ascending boluses
Context: PMID 21632807
Formulation: Route-specific sterile formulation and professional handling requirements apply; concentration cannot be inferred from an oral or topical product.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
1.5 or 4 mcg/kg/hour
Context: PMID 21632807
Formulation: Route-specific sterile formulation and professional handling requirements apply; concentration cannot be inferred from an oral or topical product.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
No route-specific amount established in the reviewed record.
Context: The catalog identifies this route, but its reviewed sources do not establish a separate amount and schedule for it.
Route safety: Non-human or laboratory exposure. It cannot be converted into a human dose.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.
Kisspeptin-10 has human physiology data but no approved self-use product. Dose-response was nonmonotonic in the cited study, with 3 mcg/kg producing less LH response than 1 mcg/kg.
Supplementary research context only. Not medical advice or a treatment recommendation.
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Published articles on this site that mention Kisspeptin-10 or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.