Insulin glargine Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

Long-acting recombinant insulin analog compound Reference approved

Also known as: Glargine, Lantus, Toujeo, Basaglar, Abasaglar, Semglee

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Quick Facts

Reference Sizes

100 units/mL (U-100), 300 units/mL (U-300)

Components

Insulin glargine

Storage

For the cited U-100 Lantus labeling: store unused product at 2–8 °C, do not freeze, and protect from direct heat and light. After first use, product-specific storage and in-use limits apply; the cited Lantus labeling specifies use within 28 days, with pen storage below 30 °C after first use. Consult the applicable product label for formulation-specific storage requirements.

Solubility

Completely soluble at approximately pH 4; has low aqueous solubility at neutral pH and forms microprecipitates after neutralization in subcutaneous tissue.

Catalog Description

Insulin glargine is a recombinant human insulin analog produced using Escherichia coli K-12. Compared with human insulin, it contains glycine in place of asparagine at position A21 and two additional arginine residues at the C-terminus of the B-chain. The acidic formulation is soluble at approximately pH 4; after subcutaneous administration, neutralization promotes formation of microprecipitates that slowly release insulin glargine, producing a relatively constant concentration-time profile without a pronounced peak. Insulin glargine products are available in U-100 and U-300 strengths.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Onset

No single fixed onset value is established in the cited labeling. U-100 labeling describes slower, prolonged absorption and a relatively constant concentration-time profile over approximately 24 hours without a pronounced peak.

Administration Routes (Research)

Subcutaneous

Reported Research Effects

Lowers blood glucose by increasing peripheral glucose uptake, particularly in skeletal muscle and adipose tissue, and by reducing hepatic glucose production.
Provides prolonged basal insulin activity with a relatively constant profile and no pronounced peak under labeled conditions.
Inhibits lipolysis and proteolysis and supports protein synthesis as part of insulin signaling.

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

Reference information is formulation- and product-label dependent. U-100 insulin glargine is labeled as a 100 units/mL subcutaneous injection; U-300 insulin glargine is available as a 300 units/mL subcutaneous injection. Official labeling describes once-daily basal administration for these products, but individualized dose selection and treatment decisions are outside this record. Insulin glargine is not labeled for intravenous administration or use in an insulin pump.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

Insulin glargine injection, for subcutaneous injection: prescribing information
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9835904f-64f5-42b3-9ac9-89e4aaa5182a (accessed 2026-10-16)

LANTUS (insulin glargine) injection: prescribing information
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6328c99d-d75f-43ef-b19e-7e71f91e57f6 (accessed 2026-10-16)

Insulin Glargine, PubChem Compound Summary CID 118984454
https://pubchem.ncbi.nlm.nih.gov/compound/Insulin-glargine (accessed 2026-10-16)

Lantus: European Public Assessment Report
https://www.ema.europa.eu/en/medicines/human/EPAR/lantus (accessed 2026-10-16)

Toujeo: European Public Assessment Report
https://www.ema.europa.eu/en/medicines/human/EPAR/toujeo (accessed 2026-10-16)

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.