Hexarelin Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: hexarelin human endocrine studies

Growth Signal Research peptide Lyophilized verified

Also known as: Examorelin

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Quick Facts

Reference Sizes

2 mg, 5 mg, 10 mg

Calculator

Preset available

Storage

Lyophilized: store at -20 deg C. After reconstitution: refrigerate 2-8 deg C; verify beyond-use timing against source COA.

Solubility

Salt and supplier formulation dependent

Catalog Description

Hexarelin is a synthetic hexapeptide GH secretagogue reported as the strongest GH-releasing agent among the GHRP class in comparative studies. Unlike ipamorelin, hexarelin activates non-GHS-R1a/CRF-related pathways, producing ACTH and cortisol release of a magnitude similar to human CRH in published comparative studies (alongside GHRP-2). It also interacts with CD36 receptors in cardiac tissue, a distinguishing feature investigated in cardioprotection research. Prolonged use has been associated with receptor desensitization in the literature.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Approximately 55 minutes for the GH response in the cited dose-response study; compound PK is less well characterized

Onset

GH peaked at about 30 minutes and returned toward baseline within four hours after IV dosing

Administration Routes (Research)

IV SC intranasal and oral in acute human studiesLaboratory use

Reported Research Effects

Strongest GH-release potency among GHRPs
Direct CD36 interaction in cardiac tissue
Measurable ACTH/cortisol co-stimulation

Reported Research Side Effects

Increased prolactin ACTH and cortisol
Flushing or appetite effects
GH and IGF-1 elevation
Long-term safety is unknown

Data source: Placebo-controlled human dose-response and route-comparison studies

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

0.5-2 mcg/kg as a single ascending endocrine challenge [IV; Single-dose human study; Once]Source: PMID 7957536
1.5 or 3 mcg/kg as an acute route-comparison dose [SC; Single-dose human study; Once]Source: PMID 8126144

Research Interactions

Flagged Avoid / Caution Combinations (Research)

Other GH secretagogues
Active malignancy or conditions where increased GH or IGF-1 signaling is undesirable

Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.

Research Notes

The former repeated 100-200 mcg and three-times-daily SC schedules were removed. Published human evidence supports acute stimulation testing, not chronic performance or anti-aging use.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

Hexarelin human dose-response study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/7957536/

Hexarelin route-comparison study — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/8126144/

GHRP-2 and hexarelin pituitary effects — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/9285939/

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.