HD1916 Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

Peptide; GLP-1 receptor agonist analogue compound Reference needs_revision Best effort · source review pending

Also known as: HD 1916, HD-1916, chemically synthesized semaglutide, semaglutide injection (HD1916)

Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes
Not standardized / source review pending
Components
Semaglutide peptide analogue

Best-Effort Research Profile

HD1916 is identified in the clinical literature as chemically synthesized semaglutide. Semaglutide is a 31-amino-acid GLP-1 analogue with albumin-binding and DPP-4-stabilizing structural modifications. HD1916 was evaluated as a once-weekly subcutaneous preparation in a phase III obesity study against reference semaglutide.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Half-Life
Approximately 1 week for semaglutide reference product; HD1916-specific half-life was not reported in the cited sources.
Onset
For semaglutide reference product, maximum plasma concentration is reached approximately 1–3 days after subcutaneous administration. HD1916-specific onset or pharmacokinetic timing was not established in the cited sources.
Administration Routes (Research)
Subcutaneous injection

Reported Research Effects

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

In the phase III study, adults with obesity received once-weekly subcutaneous HD1916 for 44 weeks, with dose escalation through 0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg, and 2.4 mg levels as recorded in the trial registry. These are study-regimen levels and are not presented as catalog package sizes or individualized dosing guidance. HD1916-specific formulation composition, excipients, concentration, storage conditions, sequence-level distinctions from semaglutide, and independent pharmacokinetic characterization were not reliably established from the authoritative sources reviewed.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

HD1916-specific chemical identifiers were not located in the authoritative sources reviewed. Parent compound semaglutide: CAS 910463-68-2; PubChem CID 56843331; molecular formula C187H291N45O59; molecular weight 4113.58 g/mol.

Source-Backed Observations

HD1916 appears to be a development or product code for a chemically synthesized semaglutide preparation rather than a distinct semaglutide analogue with a separately characterized molecular identity. The cited phase III publication reported HD1916 as therapeutically equivalent to reference semaglutide for body-weight reduction over 44 weeks in adults with obesity without diabetes; the study was funded by CSPC Baike and included company-affiliated authors.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

Efficacy and Safety of Chemically Synthesized Semaglutide Injection (HD1916) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial
https://pubmed.ncbi.nlm.nih.gov/42839752/ (accessed 2026-10-16)
Semaglutide, PubChem Compound Summary, CID 56843331
https://pubchem.ncbi.nlm.nih.gov/compound/910463-68-2 (accessed 2026-10-16)
Ozempic (semaglutide) prescribing information, Description and Clinical Pharmacology
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=35902e95-e00c-47ae-8f4e-ba17d41881ce&type=display (accessed 2026-10-16)

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Related Research Articles

Published articles on this site that mention HD1916 or one of its catalog aliases.

Related Research Tools

Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

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