Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.
Quick Facts
Reference Sizes
10 g, 100 g
Storage
Store dry at room temperature in a tightly closed container
Solubility
Freely soluble in water
Best-Effort Research Profile
Glycine is the smallest amino acid, serving as both an inhibitory neurotransmitter (glycine receptors in the spinal cord/brainstem) and a major structural component of collagen. It has been studied for sleep-quality outcomes and as a component of numerous metabolic pathways (glutathione, creatine, and purine synthesis).
Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.
Research Profile
Half-Life
Endogenous amino-acid kinetics are context dependent; a single supplement half-life is not clinically meaningful
Onset
Sleep-study outcomes were assessed the next morning after bedtime dosing
Administration Routes (Research)
OralLaboratory / preclinical
Reported Research Effects
Inhibitory CNS neurotransmission
Collagen synthesis building block
Studied for sleep-quality outcomes
Reported Research Side Effects
Gastrointestinal discomfort
Soft stools or nausea at larger doses
Sedation is possible in sleep-focused use
Data source: Small controlled human sleep study
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Route-Specific Research Protocols
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
Label / guidelineHuman studyCommunity onlyPreclinical onlyNot established
OralHuman study only
3 g before bedtime
Frequency / timing
Nightly
Duration / setting
Three nights in a sleep-restriction study
Technique
Oral
Evidence
Human study protocol
Context: PMID 22529837
Formulation: Oral-mucosal formulations are not dose-equivalent to injectable or topical formulations.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
Research Interactions
Flagged Avoid / Caution Combinations (Research)
No catalog-wide drug-interaction rule is established; account for total amino-acid and protein intake in metabolic studies
Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.
Research Notes
The prior 10-15 g collagen or methylation entry lacked a cited protocol and was removed. The 3 g sleep evidence comes from small Japanese studies and should not be generalized to treatment of insomnia.
Supplementary research context only. Not medical advice or a treatment recommendation.
Found a relevant Reddit or forum thread about this compound? Suggest it below. Every suggestion is reviewed by an editor before it appears -- nothing is published automatically.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.