GLP-2 Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: native GLP-2 human pharmacokinetics

Metabolic Research peptide Lyophilized Community-Supported (not scientifically verified)

Also known as: Glucagon-like peptide-2

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Community-Supported: unlocked based on forum/Reddit discussion, NOT on peer-reviewed or scientific verification. This content is for research and educational reference only. These compounds, protocols, and dosing figures are not verified, may not be FDA-approved, and are not intended for use in humans or animals. Always independently verify before relying on any of this information.

Quick Facts

Reference Sizes

1 mg, 5 mg

Calculator

Preset available

Storage

Per FDA label (Gattex/teduglutide): refrigerate - verify current label before recording.

Solubility

Research formulation dependent

Catalog Description

GLP-2 (Glucagon-Like Peptide-2) is an intestinotrophic hormone co-secreted with GLP-1 from intestinal L-cells, regulating the structural and functional integrity of the gastrointestinal epithelium (promoting mucosal growth, nutrient absorption, and reduced intestinal permeability). Its analog teduglutide (Gattex) - a recombinant, DPP-4-resistant GLP-2 analog - was FDA-approved on December 21, 2012 for adult short bowel syndrome patients dependent on parenteral nutritional support, with European approval extended to pediatric patients in 2016.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Intact native GLP-2 7.2 +/- 2 minutes; GLP-2(3-33) metabolite 27.4 +/- 5.4 minutes

Onset

Plasma exposure peaks within the acute study period; trophic intestinal outcomes require longer assessment

Administration Routes (Research)

IV and SC in human metabolism studiesLaboratory use

Reported Research Effects

Promotes intestinal mucosal growth and structural integrity
Improves nutrient absorption and reduces intestinal permeability
Analog (teduglutide/Gattex) FDA-approved for short bowel syndrome

Reported Research Side Effects

Gastrointestinal effects
Fluid retention or abdominal symptoms are plausible from GLP-2 activity
Long-term native-peptide safety is not established

Data source: Primary human native-GLP-2 metabolism study

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

0.8 pmol/kg/min as a native-peptide infusion [IV; Acute human metabolism study; Continuous]Source: PMID 10946898
400 mcg as a single native-peptide bolus [SC; Single-dose human metabolism study; Once]Source: PMID 10946898

Research Interactions

Flagged Avoid / Caution Combinations (Research)

Do not substitute teduglutide dosing; teduglutide is a DPP-4-resistant analogue

Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.

Research Notes

The prior row mixed native GLP-2 with teduglutide's approved daily dose. The compounds differ in sequence and half-life and must remain separate.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

Native GLP-2 human degradation and PK — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/10946898/

Community Discussion Unverified

Best-effort summary of forum/Reddit discussion. This is anecdotal community commentary, not a scientific source, and does not count toward this record's verification status. Do not treat it as established fact or medical guidance.

r/GLP1ResearchTalk - GLP-2, I'm so confused
https://www.reddit.com/r/GLP1ResearchTalk/comments/1rxkmwj/glp2_im_so_confused/

Community thread discussing confusion around GLP-2 vs other GLP-family peptides; anecdotal, not scientific verification.

r/AtomikLabz_Peptides - GLP-2 discussion
https://www.reddit.com/r/AtomikLabz_Peptides/comments/1m5kxhn/glp_2/

Vendor-community forum discussion specifically about GLP-2; anecdotal only.

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.