Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: native GLP-1 infusion physiology
Also known as: Glucagon-like peptide-1
GLP-1 (glucagon-like peptide-1) is the native incretin hormone secreted by intestinal L-cells in response to food intake, stimulating glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and acting centrally on satiety pathways. Its native half-life is only about 2 minutes due to rapid DPP-4 enzymatic degradation - this extreme instability is precisely why every approved and investigational 'GLP-1 drug' in this catalog (semaglutide, tirzepatide, liraglutide, exenatide, retatrutide, etc.) is a chemically modified analog engineered for DPP-4 resistance and extended half-life, rather than native GLP-1 itself. Native GLP-1 has essentially no standalone therapeutic research use given this instability; its primary catalog relevance is as the physiological reference point for understanding why the analog compounds are designed the way they are.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary human continuous-infusion study and native-peptide pharmacology
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.
Native GLP-1 is not interchangeable with marketed long-acting GLP-1 receptor agonists. Its minute-scale half-life generally requires continuous infusion in human studies.
Supplementary research context only. Not medical advice or a treatment recommendation.
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Published articles on this site that mention GLP-1 or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.