Intraperitoneal (IP)
Preclinical only
Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: senescent cell apoptosis mechanisms
Also known as: FOXO4 D-retro-inverso, FOXO4DRI
FOXO4-DRI is a designed retro-inverso D-peptide that disrupts the interaction between FOXO4 and p53, promoting phosphorylated p53 nuclear exclusion and triggering BAX/caspase-3-mediated apoptosis preferentially in senescent cells (sparing proliferating cells). The foundational study (Baar et al., Cell, 2017) used naturally aged mice, chemotherapy-induced senescence models, and a fast-aging XPF-ERCC1-deficient mouse strain, reporting reduced senescent cell markers and faster recovery of physical condition after cytotoxic-agent-induced senescence. Follow-up preclinical work has extended findings to senescent Leydig cells (age-related testosterone insufficiency in aged mice), pulmonary fibrosis models, and in vitro human chondrocytes. All published evidence to date is preclinical (mouse and cell culture); no human trial data exists.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Preclinical senolytic literature
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
5 mg/kg on three consecutive days in each weekly cycle
Context: Baar et al. preclinical mouse study
Route safety: Non-human or laboratory exposure. It cannot be converted into a human dose.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.
The protocol is strictly a mouse regimen and must not be interpreted as a human-equivalent schedule. No controlled human trial was located.
Supplementary research context only. Not medical advice or a treatment recommendation.
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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.