Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: cellular senescence and senolytic pharmacology
Also known as: Fisetin flavonoid
Fisetin is a plant flavonoid studied as a senolytic compound (selectively promoting clearance of senescent cells). In a Mayo Clinic pilot study, older women with osteoarthritis who took fisetin for 2 consecutive days showed decreased circulating senescence biomarkers. Fisetin is also being evaluated in the registered clinical trial NCT03430037 for effects on frailty and inflammation in older adults - one of the more advanced human senolytic trials to date, though results remain early-stage relative to the compound's broader marketing as an anti-aging supplement.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Registered human trials, trial-design publication, and preclinical senolytic study
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
20 mg/kg/day for two consecutive days followed by 28 days off
Context: NCT04210986
Formulation: Oral-mucosal formulations are not dose-equivalent to injectable or topical formulations.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
20 mg/kg/day on days 1-3 of each 14-day cycle
Context: TROFFi Phase II protocol PMID 41835341
Formulation: Oral-mucosal formulations are not dose-equivalent to injectable or topical formulations.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.
The 20 mg/kg regimen is now used in registered human research but efficacy remains investigational. Reddit's so-called Mayo protocol reflects trial dosing and is anecdotal outside trials.
Supplementary research context only. Not medical advice or a treatment recommendation.
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Published articles on this site that mention Fisetin or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.