Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: PepTools vendor-neutral scientific reference catalog
Also known as: fibroblast growth factor 21, FGF-21, UNQ3115, PRO10196
FGF21 is a 209-amino-acid human precursor protein with an N-terminal signal peptide spanning residues 1–28 and a mature secreted chain spanning residues 29–209. The UniProt-reviewed sequence has a calculated molecular mass of approximately 22.3 kDa. FGF21 belongs to the endocrine FGF19/FGF21/FGF23 subfamily and functions through receptor complexes involving beta-Klotho (KLB) and fibroblast growth factor receptors. Reported biological activities include regulation of glucose uptake, systemic glucose homeostasis, insulin sensitivity, and metabolic signaling in experimental systems.
Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
This record refers to the endogenous human FGF21 protein and its reference sequence, not to a specific recombinant formulation, engineered analog, fusion protein, or pharmaceutical product. Administration route, study dosing, pharmacokinetic half-life, onset, solubility, and storage conditions are formulation- and construct-dependent and are therefore not generalized here. Experimental effects should not be interpreted as clinical use information.
Supplementary research context only. Not medical advice or a treatment recommendation.
Human FGF21 gene: NCBI Gene ID 26291; HGNC:3678; UniProtKB/Swiss-Prot Q9NSA1; RefSeq protein NP_061986.1; RefSeq transcript NM_019113.4; Ensembl gene ENSG00000105550; CCDS12734.1; NCBI Taxonomy ID 9606.
The human reference protein is annotated as a secreted precursor. UniProt records protein-level evidence, a signal peptide at residues 1–28, the mature FGF21 chain at residues 29–209, and a disordered region at residues 143–209. Structural entries include PDB 5VAQ for a C-terminal fragment and PDB 6M6E/6M6F for the human FGF21 core domain. FGF21 activity is dependent on beta-Klotho-containing receptor complexes; reported receptor components include FGFR1c, FGFR3c, and FGFR4 in experimental systems.
Reflects published research. Educational reference — not a recommendation for use.
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Published articles on this site that mention FGF21 or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.