Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: Vendor-neutral scientific reference catalog entry for DMG-PEG2000
Also known as: PEG2000-DMG, DMG-PEG 2000, DMG-PEG-2000, DMG-PEG(2000), DMG-PEG-2K, 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, 1,2-dimyristoyl-sn-glycerol-(methoxy(polyethylene glycol)-2000, MPEG-2000 glyceryl 1,2-dimyristate, methoxypoly(ethylene glycol) dimyristoyl glycerol
DMG-PEG2000, also called PEG2000-DMG, is 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000. The molecule/material contains two C14 dimyristoyl ester chains attached to a glycerol-based scaffold and a terminal methoxy-polyethylene glycol chain with a nominal molecular mass of approximately 2000 Da. Because the PEG segment is polymeric and distributed in chain length, DMG-PEG2000 is generally treated as a polymeric lipid material rather than a single discrete molecular species. In lipid nanoparticle formulations, the PEG-lipid contributes steric stabilization and influences particle size, serum interactions, circulation behavior, cellular uptake, and nucleic-acid delivery performance.
Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Research studies have evaluated DMG-PEG2000-containing lipid nanoparticles through intramuscular, subcutaneous, and intravenous administration, but these routes apply to complete nanoparticle formulations rather than to standalone DMG-PEG2000. FDA regulatory review documents identify PEG2000-DMG as one of four lipid components in certain Moderna mRNA lipid nanoparticle formulations. Published formulation studies commonly evaluate PEG-lipid contents near 1.5 mol%, while optimization studies have tested other percentages; these are formulation parameters, not a standalone dose or administration recommendation. No reliable compound-specific standalone pharmacokinetic half-life, onset, aqueous solubility, or storage specification was established from the authoritative non-vendor sources reviewed.
Supplementary research context only. Not medical advice or a treatment recommendation.
CAS RN: 160743-62-4; FDA UNII: 9X2596CIE0; PubChem CID: 10257450; NCATS GSRS substance identifier: 9X2596CIE0; InChIKey reported by PubChem for the indexed structure: HYXWVUFYXOOASK-UHFFFAOYSA-N; nominal PEG segment: PEG 2000; polymer classification: PEGylated/polymeric lipid
Authoritative records identify DMG-PEG2000 as a polymeric substance and distinguish it from discrete small-molecule structures. PubChem provides an indexed structure and identifiers, but its displayed formula and calculated molecular weight represent a discrete database structure and should not be interpreted as the molecular weight of the PEG2000 material as a whole. The nominal molecular mass is distribution-dependent. DMG-PEG2000 should not be conflated with PEG2000-C-DMG or DSPE-PEG2000, which have different linker or lipid-anchor structures.
Reflects published research. Educational reference — not a recommendation for use.
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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.