digoxin Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

cardiac glycoside compound Reference approved

Also known as: Lanoxin, Dilanacin, Rougoxin

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Quick Facts

Reference Sizes

62.5 mcg tablet, 125 mcg tablet, 187.5 mcg tablet, 250 mcg tablet, 50 mcg/mL oral solution, 500 mcg/2 mL injection ampule (250 mcg/mL)

Storage

Product-specific storage applies. Examples in current U.S. labeling include tablets stored at 25°C with permitted excursions to 15–30°C in a dry place protected from light, and injection stored at 20–25°C with permitted excursions to 15–30°C and protected from light.

Solubility

Practically insoluble in water and ether; slightly soluble in diluted 50% alcohol and chloroform; freely soluble in pyridine.

Catalog Description

Digoxin is a cardiac glycoside derived from Digitalis lanata. Its pharmacologic actions are mediated primarily through inhibition of Na+/K+-ATPase, increasing intracellular calcium availability in cardiac tissue and producing parasympathetic effects on the sinoatrial and atrioventricular nodes. It is classified by WHO ATC as C01AA05.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Approximately 1.5 to 2.0 days in healthy volunteers with normal renal function; reported as 3.5 to 5 days in anuric patients.

Onset

Reported pharmacologic-effect onset: oral tablets approximately 0.5 to 2 hours; intravenous administration approximately 5 to 30 minutes depending on infusion rate. Reported peak effect: oral tablets 2 to 6 hours; intravenous administration 1 to 4 hours.

Administration Routes (Research)

oralintravenousintramuscular

Reported Research Effects

Na+/K+-ATPase inhibition
positive inotropic effect
negative chronotropic effect
reduced atrioventricular nodal conduction
parasympathetic autonomic effects

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

Reference strengths and dosage forms are formulation-specific and should not be treated as interchangeable without accounting for bioavailability. U.S. labeling reports oral tablet absolute bioavailability of approximately 60% to 80% and intravenous bioavailability of 100%. Digoxin is not dependent on the cytochrome P450 system for metabolism. This record is for neutral scientific and catalog reference use only.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

CAS RN 20830-75-5; PubChem CID 2724385; molecular formula C41H64O14; molecular weight 780.94 g/mol; FDA UNII 73K4184T59; WHO ATC C01AA05

Source-Backed Observations

Digoxin has a narrow therapeutic index. Approximately 50% to 70% of an intravenously administered dose is excreted unchanged in urine in healthy volunteers, and only a small fraction is metabolized. Clearance is primarily associated with renal function. The compound is practically insoluble in water and ether, slightly soluble in 50% alcohol and chloroform, and freely soluble in pyridine.

Reflects published research. Educational reference — not a recommendation for use.

Sources

Digoxin Compound Summary, PubChem CID 2724385
https://pubchem.ncbi.nlm.nih.gov/compound/digoxin (accessed 2026-09-20)

Digoxin Tablets Prescribing Information
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f9897bec-c16f-2728-e053-6394a90aecb7 (accessed 2026-09-20)

Digoxin Injection Prescribing Information
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=98d2ad5b-9ffa-4456-9a01-567636c3a4d2&type=display (accessed 2026-09-20)

Lanoxin Digoxin Injection FDA Label
https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/009330s026lbl.pdf (accessed 2026-09-20)

Anatomical Therapeutic Chemical Classification
https://www.who.int/tools/atc-ddd-toolkit/atc-classification (accessed 2026-09-20)

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.