diclofenac Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

Nonsteroidal anti-inflammatory drug (NSAID); phenylacetic acid derivative; cyclooxygenase inhibitor compound Reference needs_revision Best effort · source review pending

Also known as: Diclofenac acid, Diclofenac free acid, 2-(2-((2,6-dichlorophenyl)amino)phenyl)acetic acid, 2-[2-(2,6-dichloroanilino)phenyl]acetic acid, Diclofenal, Dicrofenac, Diclophenac

Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes
Not standardized / source review pending
Storage
Storage is formulation-specific. A diclofenac sodium delayed-release tablet label specifies storage at 25 °C, with excursions permitted from 15 °C to 30 °C, protection from moisture, and use of a tight, light-resistant container.
Solubility
Free diclofenac acid has reported water solubility of approximately 2.37 mg/L at 25 °C. Diclofenac sodium is described in official labeling as sparingly soluble in water and freely soluble in methanol; salt and formulation solubility should not be generalized to the free acid.

Best-Effort Research Profile

Diclofenac is a monocarboxylic acid and phenylacetic acid derivative with the molecular formula C14H11Cl2NO2 and molecular weight approximately 296.14 g/mol. It is classified as a nonsteroidal anti-inflammatory drug and cyclooxygenase inhibitor. Diclofenac is used in multiple pharmaceutical formulations, including oral, topical dermal, and ophthalmic products; diclofenac salts such as diclofenac sodium and diclofenac potassium are distinct chemical forms of the same active moiety.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Half-Life
Approximately 2 hours for unchanged diclofenac after oral diclofenac sodium delayed-release administration; a representative label reports a terminal half-life of approximately 2.3 hours.
Onset
Formulation-dependent. For oral diclofenac sodium delayed-release tablets, peak plasma concentrations are reached at approximately 2 hours in fasting adults, with a reported range of 1 to 4 hours. Food may delay absorption by approximately 1 to 4.5 hours.
Administration Routes (Research)
oraltopical dermalophthalmic

Reported Research Effects

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

Evidence and administration details are formulation-specific and should not be transferred between diclofenac free acid, diclofenac sodium, diclofenac potassium, topical products, or ophthalmic products. Representative official labeling describes oral diclofenac sodium delayed-release tablets in 50 mg and 75 mg strengths, but these product strengths are not recorded as compound common sizes because they are formulation- and product-specific.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

CAS RN 15307-86-5; PubChem CID 3033; ChEBI CHEBI:47381; FDA UNII 144O8QL0L1; molecular formula C14H11Cl2NO2; molecular weight 296.14 g/mol; IUPAC name 2-[2-(2,6-dichloroanilino)phenyl]acetic acid; InChIKey DCOPUUMXTXDBNB-UHFFFAOYSA-N; InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19); canonical SMILES C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl

Source-Backed Observations

The parent compound is the free acid. Diclofenac sodium and diclofenac potassium are salts and should not be treated as identical material for physicochemical or formulation records. Diclofenac sodium delayed-release, extended-release, immediate-release diclofenac potassium, topical, and ophthalmic formulations may have different absorption and exposure characteristics.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

Diclofenac, PubChem Compound Summary CID 3033
https://pubchem.ncbi.nlm.nih.gov/compound/Diclofenac (accessed 2026-09-13)
Diclofenac, ChEBI CHEBI:47381
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=47381 (accessed 2026-09-13)
Diclofenac Sodium Delayed-Release Tablets, USP: Prescribing Information
https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=6b7fb6b7-2f58-4cb6-b48f-e9b4cf292365 (accessed 2026-09-13)
Diclofenac Sodium Ophthalmic Solution, 0.1%: Official Label
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=39dfffb0-612a-48f3-8db5-1a59899b91e9 (accessed 2026-09-13)

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

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