Dasiglucagon hydrochloride Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools neutral scientific reference catalog

Glucagon analog peptide; glucagon receptor agonist; antihypoglycemic agent compound Reference approved

Also known as: Dasiglucagon, Dasiglucagon hydrochloride, Dasiglucagon hydrochloride salt, Dasiglucagon (as dasiglucagon hydrochloride), Zegalogue

Quick Facts

Reference Sizes
0.6 mg/0.6 mL single-dose prefilled syringe, 0.6 mg/0.6 mL single-dose autoinjector
Storage
For the approved aqueous drug product: store at 2°C to 8°C and do not freeze. The product may alternatively be stored at 20°C to 25°C for up to 12 months; it should remain in its protective case and should not be returned to refrigeration after room-temperature storage.

Catalog Description

Dasiglucagon hydrochloride is the hydrochloride salt of dasiglucagon, a 29-amino-acid glucagon analog. Dasiglucagon activates hepatic glucagon receptors, stimulating glycogen breakdown and glucose release from the liver. The free-base active moiety has the molecular formula C152H222N38O50 and a molecular mass of approximately 3382 g/mol; the hydrochloride form is described in the FDA labeling as a salt containing 3 to 5 equivalents of hydrochloride.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life
Approximately 30 minutes after subcutaneous administration.
Administration Routes (Research)
Subcutaneous

Reported Research Effects

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

Dasiglucagon is a stabilized glucagon analog containing seven substituted amino acids relative to endogenous glucagon. Following subcutaneous administration of 0.6 mg, mean peak plasma concentration was reported at approximately 35 minutes. Dasiglucagon is cleared through proteolytic degradation pathways in blood, liver, and kidney. No standalone authoritative solubility value for dasiglucagon hydrochloride was identified in the sources reviewed.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

Active moiety: dasiglucagon; free-base formula: C152H222N38O50; free-base molecular mass: approximately 3382 g/mol; PubChem active-moiety CID: 126961379; PubChem hydrochloride reference SID: 483927104; UNII: YQX12245A9; ChEMBL: CHEMBL4650274; NCIt: C217839.

Source-Backed Observations

The hydrochloride salt is the form used in the approved drug product. The product is described as a preservative-free, sterile, aqueous, clear, colorless solution. The labeled formulation contains dasiglucagon hydrochloride, tromethamine, sodium chloride, and water for injection; hydrochloric acid and/or sodium hydroxide may be used for pH adjustment.

Reflects published research. Educational reference — not a recommendation for use.

Sources

ZEGALOGUE (dasiglucagon) injection, FDA Prescribing Information, Revised June 2026
https://www.accessdata.fda.gov/drugsatfda_docs/label/2026/214231s004lbl.pdf (accessed 2026-08-28)
Zegalogue European Public Assessment Report and product information
https://www.ema.europa.eu/en/medicines/human/EPAR/zegalogue (accessed 2026-08-28)
Dasiglucagon hydrochloride
https://pubchem.ncbi.nlm.nih.gov/compound/Dasiglucagon%20hydrochloride (accessed 2026-08-28)
Dasiglucagon
https://pubchem.ncbi.nlm.nih.gov/compound/Dasiglucagon (accessed 2026-08-28)

Suggest a community source

Found a relevant Reddit or forum thread about this compound? Suggest it below. Every suggestion is reviewed by an editor before it appears -- nothing is published automatically.

Related Research Articles

Published articles on this site that mention Dasiglucagon hydrochloride or one of its catalog aliases.

Related Research Tools

Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

Scroll to Top