CT-388 Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

Investigational peptide-based dual GLP-1/GIP receptor agonist compound Reference needs_revision Best effort · source review pending

Also known as: Enicepatide, RO7795068, RG6640

Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes
Not standardized / source review pending

Best-Effort Research Profile

CT-388 is a signaling-biased dual agonist of the glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR). Published preclinical and clinical research describes cAMP signaling activity at both receptors with minimal receptor internalization. CT-388 has been evaluated in randomized clinical studies involving adults with overweight or obesity, including studies assessing safety, pharmacokinetics, glycemic parameters, and body-weight change.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Half-Life
Approximately 135–151 hours in a reported multiple-dose clinical pharmacokinetic analysis; an earlier clinical report described a mean half-life of approximately 150 hours.
Administration Routes (Research)
subcutaneous

Reported Research Effects

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

Phase 1 research evaluated single subcutaneous doses of 0.5–7.5 mg and four once-weekly doses in the 5–12 mg range. A later 48-week Phase 2 study evaluated once-weekly subcutaneous target doses of 4, 8, 12, 16, and 24 mg. These are study regimens reported for research reference only and are not prescribing or administration recommendations.

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

Clinical-trial and development identifiers include CT-388, enicepatide, RO7795068, and RG6640.

Source-Backed Observations

ClinicalTrials.gov classifies CT-388 as a synthetic peptide. It remains investigational and is not identified in the cited sources as an approved medicine. Publicly reported clinical data support subcutaneous once-weekly administration in studied protocols.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

Effects of CT-388, a once-weekly signaling-biased dual GLP-1/GIP receptor agonist, on weight loss and glycemic control in preclinical models and participants with obesity
https://www.sciencedirect.com/science/article/pii/S221287782500198X (accessed 2026-10-03)
A Study of CT-388 in Otherwise Healthy Overweight and Obese Adults and Patients With Type 2 Diabetes Mellitus (NCT04838405)
https://clinicaltrials.gov/study/NCT04838405 (accessed 2026-10-03)
A Study of Enicepatide (CT-388) in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity (NCT06525935)
https://clinicaltrials.gov/study/NCT06525935 (accessed 2026-10-03)
Synthesis of an intermediate and its use for the preparation of GLP-1R/GIPR agonists
https://patents.google.com/patent/WO2026030653A1/en (accessed 2026-10-03)

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Related Research Articles

Published articles on this site that mention CT-388 or one of its catalog aliases.

Related Research Tools

Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

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