Citrulline Malate Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: exercise performance and nitric oxide

Amino Acids & Nutrients amino-acid PowderCapsule verified

Also known as: L-Citrulline DL-malate

Quick Facts

Reference Sizes
250 g, 500 g, 1 kg
Storage
Store tightly closed in a cool dry place and protect powder from moisture
Solubility
Water-soluble powder; solubility and acidity vary with the citrulline-to-malate ratio

Catalog Description

Citrulline malate combines L-citrulline with malate in ratios that are not consistently standardized across commercial products. Acute resistance-exercise trials commonly studied 8 g about 40-60 minutes before exercise, with both positive and null findings. Results cannot be assumed to apply across different citrulline-to-malate ratios.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life
A formulation-wide half-life is not established because citrulline-malate products vary in ratio; plasma citrulline commonly peaks about one hour after oral dosing
Onset
Acute exercise studies administer the product about 40-60 minutes before testing
Administration Routes (Research)
Oral

Reported Research Effects

Reported Research Side Effects

Data source: Randomized exercise trials plus current retail and community market checks

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Route-Specific Research Protocols

Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.

Label / guideline Human study Community only Preclinical only Not established
Oral Preclinical only

8 g as a single pre-exercise dose

Frequency / timing
40-60 minutes before exercise
Duration / setting
Single laboratory session
Technique
Oral
Evidence
Preclinical / laboratory study

Context: randomized trials PMID 26658899 and PMID 29210953

Formulation: Oral-mucosal formulations are not dose-equivalent to injectable or topical formulations.

Route safety: Non-human or laboratory exposure. It cannot be converted into a human dose.

Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.

Research Interactions

Flagged Avoid / Caution Combinations (Research)

Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.

Research Notes

Current retail packaging is commonly 250 g 500 g or 1 kg. Reddit discussions confirm these sizes and highlight inconsistent 2:1 versus lower citrulline ratios; those reports are market context only.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

Acute citrulline malate and resistance exercise in trained females — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/26658899/
Acute citrulline malate and upper-body resistance exercise — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/29210953/
Null German Volume Training trial — PubMed Central (NIH)
https://pmc.ncbi.nlm.nih.gov/articles/PMC6086018/

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Related Research Tools

Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.

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