B7-33 Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: RXFP1 signaling and cardiac fibrosis

Signal Peptides peptide Lyophilized verified

Also known as: Relaxin family peptide B7-33

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Quick Facts

Reference Sizes

1 mg, 5 mg

Calculator

Preset available

Storage

Lyophilized: store at -20 deg C. After reconstitution: refrigerate 2-8 deg C; verify beyond-use timing against source COA. No human safety data exists - preclinical compound only.

Solubility

Peptide and salt dependent; use the synthesis-provider specification

Catalog Description

B7-33 is a minimized single-chain analog derived from the B-chain of human relaxin-2 and designed as a functionally selective RXFP1 agonist. Published evidence is preclinical, including cell signaling and rodent cardiac, lung, and fibrosis models. It has not entered established human clinical development, and vendor vial sizes do not imply a human protocol.

Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.

Research Profile

Half-Life

Not established in humans

Onset

Preclinical signaling was measured within minutes; organ-remodeling endpoints were measured over days to weeks

Administration Routes (Research)

Rodent model-dependentIn vitro

Reported Research Effects

RXFP1-biased agonism
ERK1/2-favoring signaling in preclinical systems
Reduced fibrosis and remodeling in rodent models
No human efficacy evidence

Reported Research Side Effects

No human safety profile
Long-term immunogenicity and tumor biology are unresolved
Preclinical findings only

Data source: Primary preclinical RXFP1 and cardiac-remodeling studies

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Protocols Reported in the Literature

0.25 mg/kg/day [Rodent; 14 days; Continuous study exposure]Source: preclinical cardiac-fibrosis experiment PMID 30155023

Research Notes

The prior generic SC/IV wording was removed because no human route is established. Current market sizes are niche custom-synthesis or research-vial listings and need lot-level identity confirmation.

Supplementary research context only. Not medical advice or a treatment recommendation.

Sources

A single-chain relaxin derivative is a functionally selective RXFP1 agonist — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/30155023/

B7-33 attenuates myocardial-infarction-related cardiac remodeling in mice — PubMed (NIH)
https://pubmed.ncbi.nlm.nih.gov/32295457/

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.