Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: apelin receptor and cardiovascular signaling
Also known as: APJ ligand 13
Apelin-13 is a short endogenous agonist of the apelin receptor (APLNR/APJ). The pyroglutamyl form, [Pyr1]apelin-13, is the predominant stable cardiovascular isoform in humans and should not be treated as interchangeable with every vendor-labeled apelin-13 salt. Human studies have used controlled intravenous or intrabrachial infusion to study vascular responses and metabolism. No approved therapeutic indication or validated subcutaneous protocol exists.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Primary human infusion studies plus current scientific-supplier catalogs
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
0.1-30 nmol/min local infusion
Context: human vascular physiology study PMID 18772060
Formulation: Route-specific sterile formulation and professional handling requirements apply; concentration cannot be inferred from an oral or topical product.
Route safety: Non-human or laboratory exposure. It cannot be converted into a human dose.
135 nmol/min
Context: human metabolism study PMID 31882594
Formulation: Route-specific sterile formulation and professional handling requirements apply; concentration cannot be inferred from an oral or topical product.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
No route-specific amount established in the reviewed record.
Context: The catalog identifies this route, but its reviewed sources do not establish a separate amount and schedule for it.
Route safety: Non-human or laboratory exposure. It cannot be converted into a human dose.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.
Differentiate native apelin-13 from [Pyr1]apelin-13. Current scientific suppliers commonly list 0.5 mg, 1 mg, and 5 mg packs. No published evidence supports the prior generic SC route.
Supplementary research context only. Not medical advice or a treatment recommendation.
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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.