Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: Vendor-neutral scientific reference catalog entry for Andarine (S-4/GTx-007).
Also known as: S-4, GTx-007, GTX-007, S-4 cpd, Andarine S4, 3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethylphenyl)propionamide
Andarine is a synthetic arylpropionamide androgen-receptor ligand and nonsteroidal SARM. In animal studies, S-4 showed tissue-selective anabolic activity, with effects in skeletal muscle and bone and comparatively lower activity in prostate tissue than conventional androgens. It has not been approved as a therapeutic drug by the U.S. Food and Drug Administration.
Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Preclinical pharmacology studies administered S-4 subcutaneously to castrated rats and evaluated androgenic activity through prostate and seminal-vesicle weights and anabolic activity through levator ani muscle weight. A later rat study used 3 or 10 mg/kg for 8 weeks and assessed muscle strength, lean body mass, bone mineral density, pituitary hormones, and reproductive-organ weights. Pharmacokinetic work in rats and dogs evaluated oral and intravenous administration; in dogs, oral bioavailability was reported as approximately 91% at pharmacologically relevant doses, with mean clearance of 4.6 mL/min/kg and a mean half-life of approximately 200 minutes. These are animal-study parameters, not validated human regimens. FDA materials list andarine among SARMs addressed by its safety communications and identify SARMs as unapproved drugs; WADA materials identify andarine as a prohibited SARM in sport.
Supplementary research context only. Not medical advice or a treatment recommendation.
CAS RN: 401900-40-1; PubChem CID: 9824562; molecular formula: C19H18F3N3O6; molecular weight: 441.4 g/mol; IUPAC name: (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; InChIKey: YVXVTLGIDOACBJ-SFHVURJKSA-N
The published evidence base is predominantly preclinical and analytical. Reported pharmacokinetic values are species-specific and should not be interpreted as human pharmacokinetic or dosing data. Product identity and composition cannot be inferred from internet labeling or non-authoritative commercial claims.
Reflects published research. Educational reference — not a recommendation for use.
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Published articles on this site that mention Andarine or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.