Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: 2026-09-01
Also known as: zenagamtide, NNC0487-0111
Amycretin, also known as zenagamtide and NNC0487-0111, is a long-acting unimolecular peptide designed to activate both GLP-1 and amylin receptors. It remains under clinical-trial development and has been evaluated in phase 1 and phase 2 studies involving overweight, obesity, and type 2 diabetes populations.
Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.
Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amycretin is an investigational compound, not an established approved medicine in the sources reviewed. Early clinical studies reported predominantly gastrointestinal treatment-emergent adverse events, generally mild to moderate. ClinicalTrials.gov records identify completed phase 1 and phase 2 studies, while Novo Nordisk reported in June 2026 that a phase 3 type 2 diabetes program was planned for the second half of 2026.
Supplementary research context only. Not medical advice or a treatment recommendation.
Development code: NNC0487-0111; alternate development name: zenagamtide
The peptide incorporates structural features described in the primary clinical literature as supporting prolonged exposure, including a C18 diacid-based side chain for reversible albumin binding, an N-terminal 2-aminoisobutyric-acid substitution, and C-terminal amidation. Oral amycretin has been studied with the absorption enhancer SNAC as a formulation component; SNAC is not the active peptide itself.
Reflects published research. Educational reference — not a recommendation for use.
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Published articles on this site that mention amycretin or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.