Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: mitochondrial redox and glucose metabolism
Also known as: ALA, Thioctic acid
Alpha-lipoic acid (ALA) is a mitochondrial cofactor for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes, and functions as an antioxidant in both aqueous and lipid cellular compartments (a relatively unique dual solubility among antioxidants). It has been studied clinically, notably in Europe, for diabetic peripheral neuropathy, and more broadly for oxidative-stress and metabolic-syndrome research.
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: General mitochondrial/diabetic-neuropathy clinical literature
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
600-1800 mg once daily
Context: SYDNEY 2 randomized clinical trial
Formulation: Oral-mucosal formulations are not dose-equivalent to injectable or topical formulations.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
No route-specific amount established in the reviewed record.
Context: The catalog identifies this route, but its reviewed sources do not establish a separate amount and schedule for it.
Formulation: Route-specific sterile formulation and professional handling requirements apply; concentration cannot be inferred from an oral or topical product.
Route safety: No route-specific protocol is established. Do not infer an amount from another route, component, or formulation.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
Reflects patterns reported in research/community literature only. Not a safety guarantee, medical advice, or interaction warning for human use.
Current retail products commonly use 300 mg or 600 mg capsules; bulk powder is commonly sold in 100 g, 250 g, and 500 g packs. The avoidWith entry is a safety flag because additive glucose lowering can increase hypoglycemia risk.
Supplementary research context only. Not medical advice or a treatment recommendation.
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Published articles on this site that mention Alpha-Lipoic Acid or one of its catalog aliases.
Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.