Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.
Researched for: myostatin signaling and muscle mass
Also known as: ActRIIB-Fc
ACE-031 is an activin receptor type IIB (ActRIIB)-Fc fusion protein with broad ligand specificity, blocking myostatin, GDF-11, and activin A signaling. In clinical trials, subjects gained measurable lean mass within 2-4 weeks without exercise, and thigh muscle volume increased 5-9%. However, development was discontinued after safety concerns emerged: postmenopausal women showed undesired increases in hemoglobin and decreased FSH levels, and a Phase II pediatric muscular dystrophy trial was halted due to adverse effects including nosebleeds and gum bleeding (attributed to off-target vascular/activin effects).
Catalog descriptions reflect research context only. Not a medical claim or treatment recommendation.
Data source: Published Phase I/II trial safety data
Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.
Amounts and schedules are separated by administration route. Evidence badges distinguish labels, human studies, preclinical work, community reports, and evidence gaps.
0.02-3 mg/kg single dose
Context: published Phase 1 healthy-volunteer trial
Formulation: Route-specific sterile formulation and professional handling requirements apply; concentration cannot be inferred from an oral or topical product.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
0.5-1.0 mg/kg every 2-4 weeks
Context: published Phase 2 Duchenne muscular dystrophy trial
Formulation: Route-specific sterile formulation and professional handling requirements apply; concentration cannot be inferred from an oral or topical product.
Route safety: Research-study protocol only; it is not an approved or individualized instruction and should not be extrapolated to another route.
Do not convert an amount between routes. Bioavailability, formulation, sterility, monitoring, and clinical context differ by route. Research-use context only; independently verify every cited source.
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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.