7-hydroxymitragynine-related compounds Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

kratom-derived indole alkaloid derivatives compound Reference needs_revision Best effort · source review pending

Also known as: 7-OH-related compounds, 7-hydroxymitragynine derivatives, 7-OH derivatives

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Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes

Not standardized / source review pending

Best-Effort Research Profile

7-Hydroxymitragynine-related compounds are indole or oxindole alkaloid structures based on the mitragynine and 7-hydroxymitragynine scaffolds. The category includes the naturally occurring alkaloid 7-hydroxymitragynine, the human-plasma rearrangement product mitragynine pseudoindoxyl, and synthetic derivatives such as MGM-15 and MGM-16. These substances are chemically distinct entities rather than a single compound, so compound-specific identifiers, physicochemical properties, pharmacokinetics, and reference quantities should be recorded separately when available.

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Administration Routes (Research)

oral, preclinical MGM-16 studysubcutaneous, preclinical opioid-pharmacology studies

Reported Research Effects

7-hydroxymitragynine and mitragynine pseudoindoxyl show μ-opioid-receptor activity in preclinical studies.
MGM-15 and MGM-16 were reported as μ/δ-opioid receptor agonists in in-vitro and animal experiments.
7-hydroxymitragynine-related structures have been investigated for antinociceptive and opioid pharmacology in preclinical models.
Human safety, clinical efficacy, and approved therapeutic use are not established for this compound family.

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

Because this is a heterogeneous compound family rather than one defined substance, common reference sizes, half-life, onset, solubility, storage conditions, and a unified administration profile are not scientifically appropriate. Individual records should be created for 7-hydroxymitragynine, mitragynine pseudoindoxyl, MGM-15, MGM-16, and other analogues when compound-specific authoritative data are available. Preclinical dose and route findings should remain linked to the individual compound and study, not generalized across the family.

Supplementary research context only. Not medical advice or a treatment recommendation.

Source-Backed Observations

7-Hydroxymitragynine is a minor alkaloid associated with Mitragyna speciosa. In an in-vitro human-plasma study, 7-hydroxymitragynine was converted to mitragynine pseudoindoxyl. MGM-15 and MGM-16 were synthesized as structurally modified 7-hydroxymitragynine derivatives and evaluated in preclinical opioid-receptor assays. The U.S. Federal Register identifies mitragynine pseudoindoxyl, MGM-15, and MGM-16 as distinct 7-hydroxymitragynine-related substances. This record represents a compound family and should not be interpreted as a single molecular entity.

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

7-Hydroxymitragynine (7-OH): An Assessment of the Scientific Data and Toxicological Concerns Around an Emerging Opioid Threat
https://www.fda.gov/files/drugs/published/7-hydroxymitragynin_7-oh_an_assessment_of_the_scientific_data_and_toxicological_concerns_around_an_emerging_opioid_threat.pdf (accessed 2026-09-20)

Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy
https://pmc.ncbi.nlm.nih.gov/articles/PMC7737207/ (accessed 2026-09-20)

Orally Active Opioid μ/δ Dual Agonist MGM-16, a Derivative of the Indole Alkaloid Mitragynine, Exhibits Potent Antiallodynic Effect on Neuropathic Pain in Mice
https://pmc.ncbi.nlm.nih.gov/articles/PMC6067406/ (accessed 2026-09-20)

Schedules of Controlled Substances: Temporary Placement of Mitragynine Pseudoindoxyl, MGM-15, and MGM-16 in Schedule I
https://www.govinfo.gov/content/pkg/FR-2026-08-26/pdf/2026-17429.pdf (accessed 2026-09-20)

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.