2-aminoisobutyric acid Research Reference

Catalog classification, reference sizes, lab math links, and source-backed data. Educational use only — not medical advice.

Researched for: PepTools vendor-neutral scientific reference catalog

non-proteinogenic amino acid compound Reference needs_revision Best effort · source review pending

Also known as: α-aminoisobutyric acid, alpha-aminoisobutyric acid, 2-methylalanine, α-methylalanine, 2-amino-2-methylpropanoic acid, 2-amino-2-methylpropionic acid, α,α-dimethylglycine, AIB, 2MA

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Best-effort research profile: this record has not passed full two-source scientific verification. Descriptive fields, research protocols, storage/handling notes, and interaction guidance below are shown with their evidence labels, but calculator presets and exact dosing math remain hidden until the record is verified or reaches Community-Supported status.

Quick Facts

Reference Sizes

Not standardized / source review pending

Best-Effort Research Profile

2-Aminoisobutyric acid is the achiral α-amino acid 2-amino-2-methylpropanoic acid, with formula C4H9NO2 and molecular mass approximately 103.12 g/mol. ChEBI classifies it as a 2,2-dialkylglycine and describes it as a rare non-protein amino acid associated with pyrimidine metabolism, urinary excretion, and certain fungal antibiotics. ([ebi.ac.uk](https://www.ebi.ac.uk/chebi/CHEBI27971))

Source review pending. This descriptive profile is shown from the available source material as a best-effort educational reference. It has not passed the full verification bar and is not a dosing instruction, medical claim, or treatment recommendation.

Research Profile

Reported Research Effects

Used as a nonmetabolizable or minimally metabolized amino-acid transport probe in cell, tissue, blood-brain-barrier, and imaging research; interpretation is experimental and system-dependent. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8032907/?utm_source=openai))
Reported to interact with neutral amino-acid transport systems, including system A and related sodium-dependent transport mechanisms, in mammalian cells and tissues. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/3053994/?utm_source=openai))
Aib residues in peptide models can favor α-helical conformations and disrupt β-sheet or fibril formation; these findings concern peptide-incorporated Aib rather than a demonstrated pharmacological effect of the free amino acid. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12693945/?utm_source=openai))

Data source: Primary literature, regulator records, trial registries, and identity-specific evidence search

Reflects preclinical/research literature context only. Not a medical claim, dosing instruction, or treatment recommendation.

Research Notes

Quantitative solvent-solubility measurements for α-aminoisobutyric acid have been reported in water and 12 organic solvents over 283.15–323.15 K, but a single general-purpose solubility value was not established from the authoritative sources reviewed. It is therefore omitted here. No general pharmacokinetic half-life or onset value is appropriate for this research compound across experimental systems. ([pubs.acs.org](https://pubs.acs.org/doi/abs/10.1021/acs.jced.4c00023?utm_source=openai))

Supplementary research context only. Not medical advice or a treatment recommendation.

Registry Identifiers

CAS RN: 62-57-7; PubChem CID: 6119; ChEBI: CHEBI:27971; molecular formula: C4H9NO2; molecular weight: 103.121 g/mol; IUPAC name: 2-amino-2-methylpropanoic acid; SMILES: CC(C)(N)C(=O)O; InChIKey: FUOOLUPWFVMBKG-UHFFFAOYSA-N. ([ebi.ac.uk](https://www.ebi.ac.uk/chebi/CHEBI27971))

Source-Backed Observations

ChEBI reports the neutral acid as a tautomer of the corresponding zwitterionic 2-aminoisobutanoic acid form. The compound is achiral because the α-carbon bears two identical methyl groups. ([ebi.ac.uk](https://www.ebi.ac.uk/chebi/CHEBI27971))

Reflects published research. Educational reference — not a recommendation for use.

Sources Under Review

Aminoisobutyric acid, CID 6119
https://pubchem.ncbi.nlm.nih.gov/compound/Aminoisobutyric-acid (accessed 2026-09-01)

α-Aminoisobutanoic acid, CAS RN 62-57-7
https://webbook.nist.gov/cgi/cbook.cgi?ID=62-57-7 (accessed 2026-09-01)

Transport of alpha-aminoisobutyric acid across the blood-brain barrier studied with in situ perfusion of rat brain
https://pubmed.ncbi.nlm.nih.gov/8032907/ (accessed 2026-09-01)

Transport of alpha-aminoisobutyric acid across brain capillary and cellular membranes
https://pubmed.ncbi.nlm.nih.gov/6822623/ (accessed 2026-09-01)

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Research Use Only. All content is for educational and research reference only. Not medical advice, a treatment recommendation, or guidance on human use. Compounds are not FDA-approved drugs unless specifically noted.